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1998 Fiscal Year Final Research Report Summary

Assessment of coma status in fulminant hepatic failure patients by analysis of frequency of EEG

Research Project

Project/Area Number 09671225
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

ASONUMA Kastuhiro  Kyoto University, Dpt.of Transplantation Immunology, Assistant, 医学研究科, 助手 (40202626)

Co-Investigator(Kenkyū-buntansha) UEMOTO Shinji  Kyoto University, Dpt.of Transplantation Immunology, Assistant, 医学研究科, 助手 (40252449)
INOMATA Yukihiro  Kyoto University, Dpt.of Transplantation Immunology, Associate Professor, 医学研究科, 助教授 (50193628)
TANAKA Koichi  Kyoto University, Dpt.of Transplantation Immunology, Professor, 医学研究科, 教授 (20115877)
Project Period (FY) 1997 – 1998
Keywordsliving related transplantation / fulminant hepatic failure / hepatic coma / electric encephalography monitoring
Research Abstract

The distribution of frequency of electric encephalography monitoring (DFEEG ) was analyzed to access the coma status in fulminant hepatic failure (FHF) patients and the usefulness of DFEEG for assessment of hepatic coma was evaluated in pre and post living related liver transplantation (LRLT). Recording DFEEG was non-invasive method and could be easily done on bed side. DFEEG was analyzed in FHF patients with encephalopathy who were candidates for LRLT.The analysis of frequency of EEC were performed every 10 seconds, and the distribution of the waves between 0 and 16 Hz were recorded by graphic chart for five minutes. Patients' coma grade were Ill through IV.DFEEG in non-coma patients and normal human showed average waves centering around a low frequency area. Regarding patients in hepatic coma, they showed two kinds of abnormal graphic patterns. High peaks around 2 Hz were observed in one group (45%), and kinds of abnormal scarcity of waves between 8 and 16 Hz was detected in the other ( 30%). The rest of the patients (25%) showed normal distribution. All the cases returned to normal distribution with recovery of consciousness.
There were some cases that DFEEG changed parallel with their coma status, whose coma status changed by blood exchange before LRLT.As coma status of patients improved normal on 2 day post LRLT, DFEEG returned normal just a little bit earlier than coma status.
It is suggested that as it reflects the degree of hepatic coma status in the most of the patients DFEEG is useful in evaluating coma grading in the FHF patients.

  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Y.Inomata: "Living Donor Liver Transplantation : An 8-Year Experience With 379 Consecutive Cases" Transplantation Proceedings. 31. 381 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Asonuma.K: "Growth and quality of life after living-related liver transplantation in children." Pediatric Transplantation. 2. 64-69 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Hattori: "Living-Related Liver Transplantation and Neurological outcome in Children with Fulminant Hepatic Failure" Transplantation. 65. 686-692 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kiuchi: "Living-Related donor Liver Transplantation ; Status Quo in Kyoto, Japan" Transplantation Proceedings. 30. 687-691 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田中紘一: "臓器移植の定着に向けて" Bio Clinica. 14 (3). (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上本伸二: "劇症肝炎・肝硬変に対する肝移植治療" 総合臨床. 47 (7). (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上本伸二: "肝移植の現況と将来" 臨床成人病. 28. (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 阿曽沼克弘: "生体肝移植の現況と今後の展望" 小児看護. 21. 111-114 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S. Uemoto: "Effects of hypoxemiaon early postoperative course of liver transplantation in pediatric patients with intrapulmonary shunting." Transplantaiton. 63. 407-414 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Tanaka: "Present status and prospective view of living related liver transplantation." J. HepatoBiliary pancreatic Surgery. 4. 51-70 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. Egawa: "Hepatic vein reconstruction in 152 living-related donor liver transplantation patients." Surgery. 121. 250-257 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Uemoto: "Coexistence of a graft with the preserved native liver in auxiliary partial orthotopic liver transplantation from a living donor for ornithine transcarbamylase deficiency" Transplantation. 63. 1026-1028 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kiuchi: "Living-donor Liver Transplantation in Kyoto, 1997" Clinical Transplants. 191-198 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Uemoto: "Transmission of Hepatitis B Virus from Hepatitis B Core Antibody-Positive Donors in Living Related Liver Transplantation." Transplantation. 65. 494-499 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Inomata: "Living Donor Liver Transplantation : An 8-Year Experience With 379 Consecutive Cases" Transplantation Proceedings. 31. 381 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asonuma.K: "Growth and quality of life after living-related liver transplantation in children." Pediatric Transplantation. 2. 64-69 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Hattori: "Living-Related Liver Transplantation and Neurological outcome in Children with Fulminant Hepatic Failure" Transplantation. 65 (5). 686-692 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kiuchi: "Living-Related donor Liver Transplantation ; Status Quo in Kyoto, Japan" Transplantation Proceedings. 30. 687-691 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Uemoto: "Effects of hypoxemia on early postoperative course of liver transplantaiton in pediatric patients with intrapulmonary shunting." Transplantaiton. 63 (3). 407-414 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tanaka: "Present status and prospects of living related liver transplantation" J.HepatoBiliary pancreatic Surgery. 4. 51-70 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Egawa: "Hepatic vein reconstruction in 152 living-related donor liver transplantation patients" Surgery121. (3). 250-257 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Uemoto: "Coexistence of a graft with the preserved native liver in auxiliary partial orthotopic liver transplantation from a living donor for ornithine transcarbamylase deficiency" Transplantation. 63 (7). 1026-1028 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kiuchi: "Living-donor Liver Transplantation in Kyoto, 1997" Clinical Transplants. 191-198 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Uemoto: "Transmission of Hepatitis B Virus from Hepatitis B Core Antibody-Positive Donors in Living Related Liver Transplantation." Transplantation. 65 (4) (inpress). (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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