1999 Fiscal Year Final Research Report Summary
Identification of a differentiation-related gene in the central nervous system using differential display method
| Project/Area Number |
09671429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Saga Medical School |
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Principal Investigator |
MINETA Toshihiro Saga Medical School, Faculty of Medicine, Instructor, 医学部, 助手 (20264187)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Kouzou Saga Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 (60238516)
TABUCHI Kazuo Saga Medical School, Faculty of Medicine, Professor, 医学部, 教授 (50116480)
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| Project Period (FY) |
1997 – 1999
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| Keywords | CNS development / differential display / glial differentiation / neural differentiation / neuron / oligodendrocyte / astrocyte / VASP |
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| Research Abstract |
We have used the differential display method to identify genes which are differentially expressed during CNS development. Using this approach, we have identified a novel rat cDNA (RNB6) that codes for a protein of 42 kDa and is expressed in the developing embryonic rat brain. The level of expression of RNB6 peaks on postnatal day 1 in brain tissue and gradually decrease thereafter. The predicted aminoacid sequence of RNB6 shares a 45% homology with the human actin-associated protein, vasodilator-stimulated phosphoprotein (VASP). VASP functions as a lignad for profilin, a signal-transducer for actin filament assembly. The shared homology of RNB6 and VASP suggests that RNB6 may take part in cellular motility during development of the CNS.
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[Publications] Hunter W D, Martuza R L, Feingenbaum F, Todo T, Mineta T, Yazaki T, Toda M, Newsome J T, Platenberg R C, Manz H J, and Rabkin S D: "Attenuated, replication-competent herpes simplex virus type 1 mutant G207: safety evaluation of intracerebral injection in nonhuman primates"J. Virol.. 73. 6319-6326 (1999)
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