1998 Fiscal Year Final Research Report Summary
RADIATION INJURY AND RECURRENCE AFTER HIGH-LET RADIATION THERAPY IN HUMAN GLIOMA
| Project/Area Number |
09671439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | KYOTO PREFECTURAL UNIVERSITY OF MEDICINE |
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Principal Investigator |
IMAHORI Yoshio KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 講師 (80191899)
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| Co-Investigator(Kenkyū-buntansha) |
OHMORI Yoshio KYOTO PREFECTURAL UNIVERSITY OF MEDICINE,ASSISTANT PROFESSOR, 医学部, 助手 (80240951)
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| Project Period (FY) |
1997 – 1998
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| Keywords | Glioma / High-LET therapy / Signal transduction / Radiation injury / BNCT / Diacylglycerol / Recurrence / PET |
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| Research Abstract |
(1) Signal. transduction images of primary brain tumor patients (n=7) were obtained by positron emission tomography (PET) using [11C]diacylglycerol (11C-DAG), and degree of the histological malignancy was examined. Marked enhancing uptake of 11C-DAG were demonstrated in the degree of astrocytoma (III), and glioblastoma (IV). The expansion of tumor volume shown by MRI with Gd-enhancement was observed in such cases with high uptake of 11C- DAG.The DAG-PET being useful method for evaluation of proliferation potential became clear.
(2) Signal transduction activity of glioblastoma cases was compared with that of patients with radiation injury after boron neutron capture therapy (BNCT). In patients with radiation injury who seemed as recurrence because of Gd-enhancement, signal transduction images and 18F-FDG images showed low activity. These cases can be diagnosed as radiation injury.
(3) Possibility of false positive is involved to diagnose radiation injury using the 18F-FBPA, which is a tracer of amino acid transport, and possibility of false negative is involved to diagnose recurrence in the 18F-FDG.These become the important point that size of the lesions should consider in discrimination to PET because of a limit of resolution ability. When 11C-DAG was used, the specificity is high and it can demonstrate an involvement of recurrence as positive views of 11C-DAG even if tumor has mixed part of the both lesion, radiation injury and recurrence.
[Conclusion] Signal transduction image using 11C-DAG is useful for diagnosis between radiation injury and the recurrence.
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[Publications] Imahori, Y., Ueda, S., Ohmori, Y., Sakae, K., Kusuki, T., Kobayashi, T., Takagaki, M., Ono, K., Ido, T., Fujii, R.: "Positron emission tomography based boron neutron capture therapy using boronophenylalanine for high-grade gliomas : Part-I" Clin.Cancer Res.4. 1825-1832 (1998)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Imahori, Y., Ueda, S., Ohmori, Y., Sakae, K., Kusuki, T., Kobayashi, T., Takagaki, M., Ono, K., Ido, T., Fujii, R.: "Positron emission tomography based boron neutron capture therapy using boronophenylalanine for high-grade gliomas : Part-II" Clin.Cancer Res.4. 1833-1841 (1998)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Imahori, Y., Ueda, S., Ohmori, Y., Kusuki, T., Ono, K., Fujii, R., Ido, T.: "Fluorine-18-labeled fluoroboronophenylalanine PET in patients with glioma" J.Nucl.Med.39. 325-333 (1998)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Imahori, Y., Ueda, S., Ohmori, Y., Kobori, N., Sakae, K., Kusuki, T., Takagaki, M., Kobayashi, T., Ono, K., Fujii, R., Ido, T.: Positron emission tomography boron neutron capture therapy system and clinical application to patients with malignant glioma. In : B.Larsson, J.Crawford, and R.Weireich (eds.) Advances in Neutron Capture Therapy. Volume II, Chemistry and Biology.Amsterdam : Elsevier Science Publishers B.V., 286-294 (1997)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ueda, S., Imahori, Y., Ohmori, Y., Kusuki, T., Yoshino, E., Takagaki, M., Kobayashi, T., Ono, K., Fujii, R., Ido, T.: Positron emission tomography boron neutron capture therapy system and clinical application to patients with malignant glioma. In : B.Larsson, J.Crawford, and R.Weinreich (eds.) Advances in Neutron Capture Therapy. Volume II, Chemistry and Biology.Amsterdam : Elsevier Science Publishers B.V., 280-285 (1997)
Description
「研究成果報告書概要(欧文)」より
