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1998 Fiscal Year Final Research Report Summary

EVALUATION OF NEUROLOGICAL DISORDERS USING ARTERIAL SPIN LABELING MR PERFUSION IMAGING

Research Project

Project/Area Number 09671455
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionMEIJI UNIVERSITY OF ORIENTAL MEDICINE

Principal Investigator

TANAKA Chuzo  MEIJI UNIVERSITY OF ORIENTAL MEDICINE,DEPARTMENT OF ACUPUNCTURE AND MOXIBUSTION,PROFESSOR, 鍼灸学部, 教授 (80163541)

Co-Investigator(Kenkyū-buntansha) UMEDA Masahiro  MEIJI UNIVERSITY OF ORIENTAL MEDICINE,DEPARTMENT OF ACUPUNCTURE AND MOXIBUSTION,, 鍼灸学部, 講師 (60223608)
EBISU Toshihiko  MEIJI UNIVERSITY OF ORIENTAL MEDICINE,DEPARTMENT OF ACUPUNCTURE AND MOXIBUSTION,, 鍼灸学部, 助教授 (40278510)
Project Period (FY) 1997 – 1998
KeywordsMR PERFUSION IMAGING / ARTERIAL SPIN LABELING / CEREBRAL BLOOD FLOW / GD-DYNAMIC SUSCEPTIBILITY CONTRAST / CEREBRAL INFARCTION
Research Abstract

In clinical study, cerebral perfusion images with a FAIR sequence, a kind of arterial spin labeling (ASL) method, and Gd-susceptibility contrast method were obtained by using a standard head coil on a 1.5 T clinical MRI scanner. Forty one clinical patients with various kind of neulorogical disorders were studied by MR perfusion imaging using a n and a parasagittal small meningioma showed hyper perfusion. Large size of a metastatic tumor, a glioblastoma and convexity meningioma showed heterogeneous intensity due to heterogeneous perfused region in these tumor. Using Gd-dynamic study, two cases of internal carotid artery occlusion showed abnormal perfused area in the territory of middle cerebral artery. In one case, abnormal perfused region was detected only by TTP image and this region was almost same as that of CBF image obtained by PET.All acute cortical infarction showed abnormal perfused region, however small cerebral infarction of lacuna type was not detected using Gd-perfusion images.
In animal study, quantitative cerebral perfusion images of rat brain were obtained using continuous arterial spin labeling method.The rCBF value in the normal cortex was 97.1ml/100g/min, which was similar to the reported values.
In conclusion, perfusion imaging has an extremely high potentiality to make diagnosis of various diseases, to examine the pathophysiology and to evaluate the treatment.

  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] 田中 忠蔵: "Functional MR1の原理と臨床応用" 日本臨床. 55(7). 1660-1665 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 成瀬 昭二: "拡散協調エコープラナー画像" 日本臨床. 55(7). 1616-1619 (1997)

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      「研究成果報告書概要(和文)」より
  • [Publications] 樋口 敏宏: "運動負荷と知覚刺激によるfMR2" 日本臨床. 55(7). 1688-1693 (1997)

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      「研究成果報告書概要(和文)」より
  • [Publications] 恵飛須 俊彦: "Diffusion weighted eho planar imagingを用いる臨床応用" 日本臨床. 55(7). 1742-1747 (1997)

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      「研究成果報告書概要(和文)」より
  • [Publications] 田中 忠蔵: "Multi-slice 'H-MRSIによる脳代謝マッピングと脳神経疾患の病態解析" 日本臨床. 55(7). 1779-1784 (1997)

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  • [Publications] 福永 雅喜: "Functional MRIによる三次元脳機能マッピング" 脳と神経. 49(10). 905-910 (1997)

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  • [Publications] 恵飛須 俊彦: "中枢神経疾患における拡散強調画像" 日独医報. 42(2). 187-197 (1997)

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  • [Publications] 田中 忠蔵: "EP2-頭頚部領域での有用性" 先端医療. 4(6). 22-25 (1997)

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  • [Publications] 田中 忠蔵: "高速撮像の臨床-頭頚部-" 日本磁気共鳴医学会誌. 17(7). 420-438 (1997)

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  • [Publications] 梅田 雅宏: "ファンクショナルイメージングの時代-形態から機能へ-" INNERVISION. 12(8). 83-87 (1997)

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  • [Publications] 梅田 雅宏: "脳におけるパーフェージョン/ディフュージョンイメージングの動向" INNERVISION. 12(9). 34-37 (1997)

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  • [Publications] 恵飛須 俊彦: "Diffusion Weighted Echo Phanar Imaging" 映像情報Medical. 28(25). 101-105 (1997)

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  • [Publications] T.Ebisu: "Hemorrhagic and nonhemorrhagic chokeo : Diagdasis with difusion and E weight EP2" Radiology. 203. 823-828 (1997)

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  • [Publications] 田中 忠蔵: "MRIの展望" 核医学技術. 18(4). 363-367 (1998)

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  • [Publications] 恵飛須 俊彦: "Isotrogic-diffusion weight EPIを用いた脳梗塞急性期・悪急性期の診断" Cl研究. 印刷中. (1999)

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  • [Publications] 成瀬 昭二: "脳卒中の画像診断 「Functional MRI」の項" 中外医学社, (1998)

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  • [Publications] C.Tanaka: "Proceeding of 11th International Conference or Biomagaedish" in press, (1999)

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  • [Publications] 田中 忠蔵: "脳神経外科の最先端 「拡散強調画像と脳潅流画像」" 先端技術 印刷中, (1999)

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  • [Publications] 田中 忠蔵: "実用分光法シリーズIV 「EPIおよびファンクショナルMRIの脳疾患の応用の項" アイビーシー出版 印刷中, (1999)

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  • [Publications] T.Ebisu, C.Tanaka, M.Emeda, M.Kitakura, M.Fukunaga, I.Aoki, H.Sato, T.Higuchi, S.Naruse, Y.Horikawa, S.Ueda: "Hemorrhagic and nonhemorrhagic storoke : Diagnosis with diffusion-weigted and T2-weigthed echo planar MR imaging." Radiology. 203. 823-828 (1997)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Fukunaga M,Tanaka C,Umeda M,Ebisu T,Aoki I,Higuchi T,Naruse S: "Three-dimensional brain mapping using fMRI." No To Shinkei. 49(10). 905-913 (1997)

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  • [Publications] Tanaka C,Ebisu T,Umeda M,Naruse S: "Mapping of cerebral metabolism on cerebral disorders using multi-slice proton magnetic resonance spectroscopic imaging." Nippon Rinsho. 55(7). 1779-1784 (1997)

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  • [Publications] Kitamura M,Tanaka C,Ebisu T,Umeda M: "Detection of pulsated blood flow by cine mode 3D angiography" Nippon Rinsho. 55(7). 1757-6 (1997)

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  • [Publications] Higuchi T,Fukunaga M,Umeda M,Ebisu T,Tanaka C,Naruse S,Ueda S: "Functional brain mapping in motor task and somatosensory stimulation using echo planar MRI." Nippon Rinsho. 55(7). 1688-1693 (1997)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka C,Fukunaga M,Umeda M,Ebisu T: "Theory and clinical application of functional MRI : 3D-functional brain mapping" Nippon Rinsho. 55(7). 1660-1665 (1997)

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  • [Publications] Ebisu T,Tanaka C,Umeda M,Kitamura M,Fukunaga M,Aoki I,Sato H,Higuchi T,Naruse S,Horikawa Y,Ueda S: "Hemorrhagic and nonhemorrhagic stroke : diagnosis with diffusion-weighted and T2-weighted echo-planar MR imaging." Radiology. 203(3). 823-828 (1997)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Ebisu T,Tanaka C,Umeda M,Naruse S: "Principles and clinical applications of diffusion weighted MR imaging." Nichidokuiho. 42(2). 187-197 (1997)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka C: "Clinical application of fast MRI ; Neurological disorders" Jpn J Magn Reson Med. 17(7). 420-438 (1997)

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  • [Publications] Tanaka C,Fukunaga M,Ebisu T,Umeda M,Aoki I: "Clinical application of functional MRI Proceeding of IIth International Conference on Biomagnetism." (in press). (1999)

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Published: 1999-12-08  

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