• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1999 Fiscal Year Final Research Report Summary

Pulmonary administration of vasodilators during partial liquid ventilation in ARDS.

Research Project

Project/Area Number 09671541
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTokyo Medical & Dental University

Principal Investigator

KOICHI Nakazawa  Tokyo Medical & Dental University, Anesthesiology, Associate Professor, 大学院・医歯学総合研究科, 助教授 (10207756)

Co-Investigator(Kenkyū-buntansha) YOKOYAMA Kuninori  Tokyo Medical & Dental University, Assistant Professor, 医学部, 助手 (00014176)
UCHIDA Tokujiro  Tokyo Medical & Dental University, Assistant Professor, 医学部, 講師 (40262183)
MAKITA Koshi  Tokyo Medical & Dental University, Professor, 大学院・医歯学総合研究科, 教授 (20199657)
MATSUZAWA Yoshiyasu  Tokyo Medical & Dental University, Assistant Professor, 医学部, 助手 (90311654)
Project Period (FY) 1997 – 1999
KeywordsARDS / Perflubron / Liquid ventilation / Partial liquid ventilation
Research Abstract

Partial liquid ventilation (PLV) is a new mechanical ventilation strategy for the treatment of ARDS.Gas exchange can be performed through intratracheally administered perfluorocarbon using conventional gas ventilation. The aim of our research was to investigate how to improve gas exchange during PLV.In the first study, we found that incease in gas tidal volume, administration dose of perflubron and PEEP was effective for improving gas exchange during PLV and gas tidal volume was most important for improving PaO2 We also investigated the effects of pulmonary administration of vasodilators during liquid ventilation on gas exchange and pulmonary circulation in oleic acid lung injury using rabbit. The administration of aerosolized prostacyclin and nitric oxide in combination with PLV improved PaO2 better than each treatment alone. The mean pulmonary artery pressure significantly decreased with aerosolized prostacyclin or nitric oxide in combination with PLV.Systemic blood pressure was not decreased with those treatments. Intratracheal vasodilators combined with PLV not only improves PaO2, but also reduces the PAP and PVR, leading to systemic circulatory improvement in rabbits with acute respiratory distress syndrome. These findings suggest that intratracheal vasodilators during PLV may offer a simple, alternative treatment for acute respiratory distress syndrome with pulmonary hypertension.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Nakazawa K.: "Treatment of pulmonary hypertension and hypoxia due to oleic acid induced lung injury with intratracheal prostaglandin E1 during partial liquid ventilation."Anesthesiology. 89. 686-92 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakazawa K.: "Treatment of hypoxia due to oleic acid induced lung injury with intratracheal prostacyclin during partial liquid ventilation."Anesthesiology. 89. A1377 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchida T: "The combination of partial liquid ventilation and inhaled nitric oxide in the severe oleic acid lung injury model."Chest. 113. 1658-66 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakazawa K.: "Aerosolized prostacyclin during partial liquid ventilation in an experimental model of ARDS."Anesthesiology. 91. A1378 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中沢弘一: "液体換気"救急医学. 23. 917-20 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 槙田浩史: "ウサギ急性肺障害における部分的液体換気による酸素化能改善とパーフルブロン分布の関係-核磁気共鳴による研究"日本集中治療医学会雑誌. 6. 15-20 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishikawa S., Nakazawa K., Yokoyama K.Amaha K.: "Amrinone improves right ventricular ejection fraction and oxygen delivery without deterioration of extravascular lung water in canine oleic acid pulmonary injury."Anesth & Intensive Care.. 26. 355-59 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakazawa K, Uchida T, Matsuzawa Y, Yokoyama K, Makita K, Amaha K :: "Treatment of pulmonary hypertension and hypoxia due to oleic acid induced lung injury with intratracheal prostaglandin E1 during partial liquid ventilation."Anesthesiology. 89. 686-92 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakazawa K, Uchida T, Matsuzawa Y, Yokoyama K, Makita K, Amaha K :: "Treatment of hypoxia due to oleic acid induced lung injury with intratracheal prostacyclin during partial liquid ventilation."Anesthesiology. 89 suppl.. A1377 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchida T, Nakazawa K, Yokoyama K, Makita K, Amaha K :: "The combination of partial liquid ventilation and inhaled nitric oxide in the severe oleic acid lung injury model."Chest. 113. 1658-66 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakazawa K, Uchida T, Matsuzawa Y, Yokoyama K, Makita K :: "Aerosolized prostacyclin during partial liquid ventilation in an experimental model of ARDS."Anesthesiology. 91 suppl.. A1378 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchida T, Yokoyama K, Nakazawa K, Makita K : Inhaled: "nitric oxide during partial liquid ventilation shifts pulmonary blood flow to the non-dependent lung regions"Intensive Care Med. 26. 764-769 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2002-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi