1999 Fiscal Year Final Research Report Summary
PATHOGENESIS OF ACQUIRED RENAL CYSTIC DISEASE OF THE KIDNEYS WITH TUMOR GENESIS -EXPERIMENTAL STUDY-
| Project/Area Number |
09671633
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | KAGAWA MEDICAL UNIVERSITY |
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Principal Investigator |
FUJITA Kiyoshi KAGAWA MEDICAL UNIVERSITY, DEPARTMENT OF UROLOGY, ASSISTANT PROFESSOR, 医学部・附属病院, 講師 (10145089)
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| Co-Investigator(Kenkyū-buntansha) |
KUWATA Yoshihiro KAGAWA MEDICAL UNIVERSITY, DEPARTMENT OF UROLOGY, RESEARCH ASSOCIATES, 医学部・附属病院, 助手 (30294763)
ZHANG Xianghua KAGAWA MEDICAL UNIVERSITY, DEPARTMENT OF UROLOGY, RESEARCH ASSOCIATES, 医学部, 助手 (30274286)
TAKETA Shigeo KAGAWA MEDICAL UNIVERSITY, DEPARTMENT OF UROLOGY, ASSISTANT PROFESSOR, 医学部・附属病院, 講師 (10227027)
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| Project Period (FY) |
1997 – 1999
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| Keywords | ACDK / RENAL CELL CARCINOMA / CHRONIC RENAL FAILURE / ラット / ストレプトゾトシン / シュウ酸カルシウム |
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| Research Abstract |
Haemodialysis improved the prognosis of CRF patients. But acquired cystic disease of kidney (ACDK) occurred in original kidneys in long survival cases, which have higher rates of the incidence of renal cell carcinoma(RCC). Whenever it is thought that mucous membranes of ACDK acquired the ability of growth and become to adenocarcinoma through adenoma, its mechanism is still in the dark. In our study we tried to make Rat-ACDK models and researched the roles of the growth factors on its mechanism. 50 SD rats (6 week) were divided into 4 groups. Group A : Control. Group B : forced to intake OXCa 50g cach orally to make ACDK, Group C : forced to drink streptozotocin(SZ) 0.6g each in water to make RCC, Group D : OXCa 50g and SZ 0.6g were fed. 90 days later we gamed the rats and compared with them using HE stained, immunohistochemical stained (cytokeratin and bimentin) and TUNEL stained tissues. As a result we could made renal cysts on Group B and D.But the cysts didn't have RCC.
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