1998 Fiscal Year Final Research Report Summary
The mast cell growth factor (stem cell factor) production in nasal epithelial cells.
| Project/Area Number |
09671765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
KOYAMA Mamoru Nippon Medical School, 医学部, 助手 (60267169)
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| Project Period (FY) |
1997 – 1998
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| Keywords | stem cell factor / allergic rhinitis / epitherial cell / mast cell |
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| Research Abstract |
Inimunohistiochemically, SCF was identified in the nasal epithelium of the biopsy specimens and in cultured nasal epithelial cells. SCF mRNA was exmpressed by cultured nasal epithelial cells not only in patients with allergy. However, the SCF/BETA-actin mRNA ratio and SCF production in day 7 cultured epithelial cells was significantly higher in aller- gic than in nonallergic subjects. SCF production from nasal scrapings in culture was strongly correlated with the number of mast cells and the histamine content.
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