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2000 Fiscal Year Final Research Report Summary

International collaboration study on breast cancer

Research Project

Project/Area Number 10045073
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionWakayama Medical University

Principal Investigator

KAKUDO Kennichi  Department of Pathology, Wakayama Medical University, professor, 医学部, 教授 (00112037)

Co-Investigator(Kenkyū-buntansha) UTSUNOMIYA Hirotosi  Department of Pathology, Wakayama Medical University, assistant professor, 医学部, 講師 (60264876)
MORI Ichiro  Department of Pathology, Wakayama Medical University, associate professor, 医学部, 助教授 (10157852)
SAKURAI Takeo  Department of Surgery, Wakayama Medical University, professor, 医学部, 教授 (00073700)
中村 靖司  和歌山県立医科大学, 医学部, 助手 (60275352)
NAKAMURA Misa  Department of Pathology, Wakayama Medical University, instructor, 医学部, 助手 (70285386)
Project Period (FY) 1998 – 2000
Keywordsbreast cancer / pathology / estrogen receptor / androgen receptor / prostatic specific antigen / calcitonin receptor / vitamin D receptor
Research Abstract

A comparative study of breast cancer between Chinese and Japanese cases were carried out on 100 cases from each countries. It showed sight differences in frequency of histologic subtypes and this maybe due to the difference in histopathologic criteria used. Further collaboration study to establish a unified criteria is planning. Immunohistochemical and molecular genetic studies on breast cancer from both countries disclosed the following new contributions, which were listed in the references. 1.Immunohistochemical expression of estrogen receptor was found in 61cases out of 142 breast cancer which correlated well to biochemical analysis. In ER positive cases, extensive ductal component were found more in outside of the main tumor. 2.Allelic frequency of calcitonin receptor gene is not a risk factor for the development of breast cacer in Japanese. 3.PSA mRNA expression was significantly more frequent in breast cancer patient with A allele. 4. Bcl-2 positive breast cancer have more susceptibility to anticancer drugs. 5. Immunohistochemical analysis of androgen receptor in 114 breast cancer revealed negative expression in 17cases. No point mutation was found but active alle loss in 11cases., which may contribute to loss of expression.

  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] 谷口恵美子,覚道健一 他: "骨軟骨を形成する乳癌悪性腫瘍-骨肉腫の1例-"日本臨床細胞学会雑誌. 38. 272-275 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Jing X,Kakudo K, et al: "Intraductaral spread of invasion breast carcinoma has positive correlation"Cancer. 86. 439-448 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shan L,Kaktudo K,et al: "Clonal emergence in uremic parathyroid hyperplasia is not related to MEN1"Jap J Cancer Res. 90. 965-969 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura M,Kakudo K, et al: "Genetic variants of calcitonin receptors and breast cancer in Japanese"The Breast. 8. 104-106 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yang Q,Kakudo K, et al: "Expression of Bcl-2, but not Bax, correlates with estrogen receptor"Pathol Int. 49. 755-780 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kishikawa S,Kakudo K, et al: "Overexpression and genetic abnormality of p53 in parathyroid adenom"Pathol Int. 49. 853-857 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura M,KaKudo K, et al: "The worldwide controversy about the polymorphism of the vitamin D receptor"Medical Hypothesis. 54. 495-497 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 覚道健一 他: "各臓器・領域で用いられる抗体とその応用(9)内分泌C 副甲状腺"病理と臨床(臨時増刊号)別刷. 13(1). 158-159 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 覚道健一 他: "穿刺細胞診の精度管理-施設の経年変化-"奈良県医師会医学会年報. 13(1). 13-16 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yang Q,Kakudo K, et al: "Expression of Bcl-2 but not Bax or p53 correlates with in vitro resistance to a"Breast Cancer Res and Treatment. 61. 211-216 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shan L,Kakudo K, et al: "Active allele loss of the androgen receptor gene contributes to loss of"Biochem and Biophy Res Commun. 275. 488-492 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yang Q,Kakudo K, et al: "Novel polymorphisms of prostate-specific antigen (PSA) gene associated with"Journal of Human Genetics. 45(6). 363-366 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamauchi M,Kakudo K, et al: "A case of ectopic thyroid in lateral necK associated with Grave's diseas"Endocrine J. 46(5). 731-734 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katoh R,Kakudo K, et al: "Accumulated basement membrane material in hyalinizing frabecular"Modern Pathol. 12(11). 1057-1061 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kai M,Kakudo K, et al: "Quantitative and qualitative analysis of stain color using RGB"Analyt Quant Cytol Histol. 21. 477-480 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yang Q,KaKudo K, et al: "Thymidine phosphorylase expression in invasive carcinoma : correlation"Anticancer Res. 19. 5543-5546 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tang W,Kakudo K,et al: "Thymidine phosphorylase expression in tumor stroma of uterine"Cancer Letters. 148. 153-159 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naganuma H,Kakudo K, et al: "Optically clear nuclei in papillary carcinoma of the thyroid"Pathology International. 50. 153-159 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yang Q,Kakudo K, et al: "Thymidine phosphorylase expression correlates with tumor differentiation and"Breast Cancer. 7. 210-214 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taniguchi E, Kakudo K, et al: "Cytologic grading of invasive breast carcinoma.-Correlation with"Acta Cytologica. 44(4). 587-591 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Jing X et al: "Extensive intraductal component (EIC) and estrogen receptor (ER) status in breast cancer."Pathol Int. 48. 440-447 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura M et al: "Genetic variants of calcitonin receptor and breast cancer in Japanese."The Breast. 8. 104-106 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yang Q et al: "Novel polymorphism of prostate-specific antigen (PSA) gene associated with PSA mRNA expression in breast cancer."J Hum Gent. 45. 363-366 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yang Q et al.: "Expression of Bcl-2 not Bax or p53 correlates with in vitro resistance to a series of anticancer drugs in breast"Breast Cancer Res and Treat. 61. 211-216 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shang L et al.: "Active alle loss of the androgen receptor gene contributes to loss of androgen receptor expression in female breast cancers."Biochem Biophys Res Commn. 275. 488-492 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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