| Project/Area Number |
10307033
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| Research Category |
Grant-in-Aid for Scientific Research (A).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Tokyo |
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Principal Investigator |
TAKAMOTO Shinichi University of Tokyo, Department of Cardiothoracic Surgery, Professor, 医学部・附属病院, 教授 (60137833)
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| Co-Investigator(Kenkyū-buntansha) |
KYO Shunei Saitama Medical School, Department of Surgery, Professor, 教授 (30153232)
TABAYASHI Koichi Tohoku University, Department of Surgery, Professor, 医学部, 教授 (90142942)
KITAMURA Soichiro National Cardiovascular Center, Director General of the Hospital, 院長 (10028607)
ISOBE Mitsuaki Tokyo Medical & Dental University, Department of Cardiovascular Medicine, Professor, 医学部, 教授 (80176263)
MATSUZDA Hikaru Osaka University, Department of Surgery, Professor, 医学部, 教授 (00028614)
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| Project Period (FY) |
1998 – 2000
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| Keywords | Heart transplantation / Lung transplantation / Ischemia-reperfusion injury / rejection / gene transfer therapy / early detection of rejection / left ventriular assist device / clinical study |
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| Research Abstract |
This research aimed to achieve the optimal control of the recipients with heart or heart-lung transplantations and good practice of donor hearts and lungs. Ischemia-reperfusion injury of the heart was studied on a neutrophil elastase inhibitor, superoxides and its scavengers. Reperfusion injury of the lung was studied on the point of ion transport on the alveolar cell membrane. Expression of cytokines(HGF, VEGF)in the donor heart tissue was suggested to be one of the indicators for rejection. Experimental gene transfer treatment of the donor heart was examined : In vivo transfection of E2F or NFkB decoy attenuated rejection. Macrophage scintigram and echocardiogram were examined for rejection. Usefulness of ischemic pre-conditioning of the donor hearts was studied. Left ventricular assist devices was clinically studied. Five cases of clinical heart transplants from brain-death donors in our country were reported.
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