2000 Fiscal Year Final Research Report Summary
A Study on Mechanism for Development and Progression of Metal-related Lung Disease
| Project/Area Number |
10470094
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Fukui Medical University School of Medicine |
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Principal Investigator |
KUSAKA Yukinori Department of Environmental Health, School of Medicine, Fukui Medical University Professor, 医学部, 教授 (70135680)
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| Co-Investigator(Kenkyū-buntansha) |
NAGASAWA Sumio Department of Environmental Health, School of Medicine, Fukui Medical University Lecturer, 医学部, 助手 (80293413)
SATO Kazuhiro Department of Environmental Health, School of Medicine, Fukui Medical University Assistant Professor, 医学部, 講師 (40262620)
FUKUDA Masaru Department of Pathology, School of Medicine, Fukui Medical University Professor, 医学部, 教授 (60079720)
SUGANUMA Narafumi Department of Environmental Health, School of Medicine, Fukui Medical University Lecturer, 医学部, 助手 (50313747)
YOSHIDA Yasuhiro Department of Environmental Health, School of Medicine, Fukui Medical University Lecturer, 医学部, 助手 (00303371)
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| Project Period (FY) |
1998 – 2000
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| Keywords | Nickel / Cobalt / Inflammation / Reactive Oxygen Species / Fibrosis / Tumor Necrosis Factor-alpha / DNA damage / Apoptosis |
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| Research Abstract |
Exposure to cobalt and nickel cause pneumonitis, pulmonary fibrosis, asthma and lung cancer. The model for pneumonitis resulting in pulmonary fibrosis was developed in the rat with tracheal instillation of ultrafine cobalt or nickel. At the stage of acute inflammation in the rat lungs reactive oxygen species (ROS) and tumor necrosis factor-alpha were involved. DNA plasmid assay showed carcinogenic potential of both cobalt and nickel. Bcl-2 protein related to apoptosis was also found to express. Taken together, these finding suggest that lung toxicity of cobalt or nickel generate ROS which damage DNA, and that the generation of ROS induce production of TNT-alpha. Further studies are needed on the role of apoptosis in metal-related lung diseases.
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