1999 Fiscal Year Final Research Report Summary
The common mechanisms for the determination of organ identity
| Project/Area Number |
10480207
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
KURATA Shoichiro Graduate School of Pharmaceutical Sciences, Tohoku Univ., Associate Professor, 大学院・薬学研究科, 助教授 (90221944)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Organogenesis / Notch signaling / Master control genes |
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| Research Abstract |
The Notch signaling pathway defines an evolutionarily conserved cell-cell interaction mechanism that throughout development controls the ability of precursor cells to respond to developmental signals.
Here we show that Notch signaling regulates the expression of the master control genes eyeless, vestigial, and Distal-less, which in combination with homeotic genes induce the formation of eyes, wings, antennae, and legs. Therefore, Notch is involved in a common regulatory pathway for the determination of the various Drosophila appendages.
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