2001 Fiscal Year Final Research Report Summary
Preparation and Utilization of Functional Conjugate Containing Salmon Milt DNA
| Project/Area Number |
10555327
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
高分子構造・物性(含繊維)
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| Research Institution | HOKKAIDO UNIVERISTY |
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Principal Investigator |
NISHI Norio Hokkaido Univ. Graduate School of Environmental Earth Science, 大学院・地球環境科学研究科, 教授 (70001857)
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| Co-Investigator(Kenkyū-buntansha) |
KAKUCHI Toyoji Hokkaido Univ. Graduate School of Engineering, 大学院・工学研究科, 教授 (80113538)
SAKAIRI Nobuo Hokkaido Univ. Graduate School of Environmental Earth Science, 大学院・地球環境科学研究科, 教授 (60153863)
NISHIMURA Shin-ichiro Hokkaido Univ. Graduate School of Science, 大学院・理学研究科, 教授 (00183898)
TAIRA Toshio Sangi Co. LtD. Hokkaido Inst., 北海道研究所, 研究プロジェクト課長
YAMADA Hideaki Kuraray Co. LtD., メディカル開発グループ, 開発主管(研究職)
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| Project Period (FY) |
1998 – 2001
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| Keywords | Salmon milt DNA / functional conjugate / DNA-collagen conjugate / DNA-alginic acid conjugate / insolubilized DNA film / DNA-chitosan conjugate / environmental hormone / surgical use |
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| Research Abstract |
DNA, one of the most inportant materials for life processes, can be regarded as a naturally occurring and highly specific functional biopolymer.
However, DNA is water-soluble and biochemically unstable. These weak points have to be improved for the utilization of DNA. We have prepared various DNA-materials by conjugation with other biopolymer, such as alginic acid or collagen, or UV-induced cross-linking reaction. These DNA containing materials were water-insolubilized and still retained the specific function of native DNA. Thus, these materials could be used in biomedical and also environmental field, preparing the DNA-chitosan bilayer membrane and DNA-collagen fibrous membrane for surgical use and also water-insoluble DNA film to accumulate environmental hormone.
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