2001 Fiscal Year Final Research Report Summary
Investigation of the method of the treatment for tracheal stenosis using prosthetic trachea and/or transplantation of tracheal homograft
| Project/Area Number |
10671240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | CHIBA UNIVERSITY |
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Principal Investigator |
BABA Masayuki University, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (00143305)
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| Co-Investigator(Kenkyū-buntansha) |
IIZASA Toshihiko Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (10272303)
SAITOH Yukio Chiba University, Hospital Lecturer, 医学部・附属病院, 講師 (60261905)
FUJISAWA Takehiko Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (80110328)
SEKINE Yasuo Chiba University, University Hospital, Assistant, 医学部・附属病院, 助手 (70312957)
SHIBUYA Kiyoshi Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (20302565)
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| Project Period (FY) |
1998 – 2001
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| Keywords | trachea / freezing preservation / rabbit / transplantation / MHC class antigen |
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| Research Abstract |
(Study 1) Materials and Methods : We studied the period that rejection were weakest in tracheal graft of rabbits, which was influenced by MHC Class □ antigen, and that the epithelium of tracheal graft might be able to regenerate.
RESULTS : We found that MHC class □ antigen was decreased over 8 weeks after tracheal graft was preserved in cryogen and MHC class □ antigen was disappeared 20 weeks after that. In two of three cases, the epithelium oftracheal graft were not recovered 16 weeks after that. CONCLUSION : 8 weeks to 12 weeks were best periods to preserve tracheal graft in cryogen. Further study was needed to clarify this findings.
(Study 2) Materials and Methods : The cytologic findings of the tumor cells corresponding to the stages in thymomas were investigated to assess their infiltrating nature.
RESULTS : Compared with cytologic findings of stage I or II thymomas, those of epithelial tumor cells in stage III or IV more frequently revealed necrotic background (50.0 %-stage III or IV vs 11.1 %- stage I or II, p=0.006), large cluster of epithelial tumor cells (70.0 % vs 36.1 %, p=0.055), marked nuclear enlargement (90.0 % vs 52.7 %, p=0.033), marked anisokaryosis (100 % vs 52.7 %, p=0.006), marked nuclear polymorphism (40.0 % vs 5.5 %, p=0.004), hyperchromasia (50.0 % vs 11.4 %, p=0.007) and prominent nucleoli (50.0 % vs 16.6 %, p=0.028)
CONCLUSION : Our findings revealed that there was a significant difference in the cytologic findings of epithelial tumor cells between stage I or II thymomas and stage III or IV those, and the cytologic findings of thymoma tumor cells appears to capacitate to distinguish between non invasive and invasive thymomas.
(Study 3) OBJECTIVE : We studied the utility of Endobronchial ultrasonography (EBUS) to observe the bronchial cartilage.
Conclusion : EBUS was very useful to observe the tracheal cartilage and we were able to examine the tracheal wall.
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[Publications] Baba, M., Nomoto, Y., Iyoda, A., Shibuya, K., Hoshino, H., Haga. H., Saitoh, H., Iizasa, T., Fujisawa, T.: "Cytomorphologic features corresponding to the stages of thymomas"Oncology Reports. 8. 1139-1143 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Baba, M., Sekine, Y., Suzuki, M., Yoshida, S., Shibuya, K., Iizasa, Y, Saitoh, Y, Onuma, E.K., Ohwada, H., Fujisawa, T.: "Correlation between endobronchial ultrasonography (EBUS) images and histologic findings in normal and tumor-invaded bronchial wall"Lung Cancer. 35. 65-71 (2002)
Description
「研究成果報告書概要(欧文)」より
