QUANTITATIVE ANALYSIS OF VASCULAR DEVELOPMENT

2001 Fiscal Year Final Research Report Summary

• Project/Area Number: 10671674
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: TOKYO WOMEN'S MEDICAL UNIVERSITY
• Principal Investigator: SHINOKA Toshiharu TOKYO WOMEN'S MEDICAL UNIVERSITY, Associate Professor, 医学部, 講師 (20192122)
• Co-Investigator(Kenkyū-buntansha): YOSHIGE Masayoshi TOKYO WOMEN'S MEDICAL UNIVERSITY, Assistant Professor, 医学部, 助手 (50246518)
• Project Period (FY): 1998 – 2001
• Keywords: EMBRYO / CARDIOVASCULAR DEVELOPMENT / WINDKESSEL MODEL / ORDINARY DIFFERENTIAL EQUATION

Research Abstract

We have evaluated several lumped parameter analog models for the early embryonic vascular system that may be used to infer loading characteristics of the developing heart. We measured dorsal aortic pressure and flow simultaneously with a servo-null pressure system and a pulsed Doppler velocimeter. Four different analog circuit models were chosen for comparisons. We formulated the time-domain differential equations specifying the relations between pressure and flow in the models, and then estimated the lumped parameters that produced the best fit. The MLAB mathematical modeling software was used for solving differential equations, and for minimizing the difference between model-predicted values and experimental data. The traditional three-element Windkessel model with an added inductance term was most often the best-fitting model. This is compatible with the previous study using a frequency-domain approach.9 The procedures developed for the current study are adaptable for the study of a variety of nonlinear models, and distributed parameter models for mammalian cardiovascular development with mechanically, pharmacologically, or genetically altered conditions.