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1999 Fiscal Year Final Research Report Summary

Direct Hemoperfusion with Polymyxin B Immobilized Fiber (PMX) in Acute Lung Injury Induced by Endotoxemia in Anesthetized Sheep

Research Project

Project/Area Number 10672261
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionShinshu University

Principal Investigator

HONDA Takayuki  School of Medicine, Shinshu University, Associate Professor, 医学部, 助教授 (80238815)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Keisaku  University Hospital, Shinshu University, Assistant, 医学部附属病院, 助手 (70242691)
芝本 利重  信州大学, 医学部, 助教授 (90178921)
KUBO Keishi  School of Medicine, Shinshu University, Professor, 医学部, 教授 (80143965)
KOIZUMI Tomonobu  University Hospital, Shinshu University, Assistant, 医学部附属病院, 助手 (20273097)
Project Period (FY) 1998 – 1999
KeywordsAcute lung injury / Acute respiratory distress syndrome / Endotoxemia / anesthetized sheep / Lung lymph fistula / Polymyxin B Immobilized Fiber (PMX) / Shock / Respiratory failure
Research Abstract

We have performed the following 2 projects under the grant.
(1) In anesthetized sheep with lung lymph fistula and systemic and pulmonary hemodynamic monitoring, we evaluated the effect of direct hemoperfusion with Polymyxin B immobilized fiber (PMX) in acute lung injury (ALI) induced by E. coli endotoxemia (10 μg/kg). Endotoxemia produced shock (decreased systemic blood pressure), pulmonary hypertension, circulating leukopenia and hypoxemia during the early phase after endotoxcmia and the increases in lung lymph flow, suggesting permeability edema, during the late phase. Direct hemoperfusion (60ml/hr) with PMX significantly improved the shock and hypoxemia induced by endotoxemia, though it did not changes the time course of leukopenia, pulmonary hypertension and lung lymph dynamics.
(2) We tried to treat 8 patients with ALI and acute respiratory distress syndrome (ARDS) using direct hemoperfusion with PMX. After 2 times of the treatment, systolic systemic pressure (from 105 ± 8 mmHg to 137 ± 5), diastolic pressure (from 63 ± 10 mmHg to 78 ± 7 mmHg) and PaO2/FiO2 (P/F ratio) (from 130 ± 20 to 170 ± 15) were significantly improved.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Hanaoka M, 他: "Interferon-α elevates pulmonary blood presure in sheep - the role of thromboxane cascade"Eur J Pharmacol. 370. 145-151 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koizumi T, 他: "Lung lymph response to overinfusion with hydroxyethl starch in sheep"Acta Anaesthesiol Scand. 43(in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hachiya T, 他: "Expression patterns of type II pneumocyte apical surface glycoconjugates in lung adenocarcinoma cells"Virchows Arch. 434. 63-69 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayasaka M, 他: "Proliferation of type II pneumocytes and alteration in their apical surface membrane antigenicity in pulmonary sarcoidosis"Chest. 116. 477-483 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyahara T, 他: "Endothelin receptor blockable attenuates air embolization-induces pulmonary hypertension in sheep"Eur J Pharmacol. 385. 163-169 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Honda T, 他: "Type II pneumocytes are preferentially located along thick elastic fibers forming the framework of human alveoli"Anat Rec. 258. 34-38 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hanaoka et al.: "Interferon-α elevates pulmonary blood pressure in sheep-the role of thromboxane cascade."Eur J Pharmacol. 370. 145-151 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koizumi et al.: "Lung lymph response to overinfusion with hydroxyethl starch in sheep."Acta Anesthesiol Sandc. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hachiya, et al.: "Expression patterns of type II pneumocyte apical surface glycoconjyugates in lung adenocarcinoma cells."Virchows Arch. 434. 63-69 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayasaka et al.: "Proliferation of type II pneumocytes and alteration in their apical surface membrane antigenicity in Pulmonary sarcoidosis."Chest. 116. 477-483 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyahara et al.: "Endothelin receptor blockade attenuates air embolization-induced pulmonary hypertension in sheep."Eur J Pharmacol. 385. 163-169 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Honda et al.: "Type II pneumocytes are preferentially located along thick elastic fiber forming the framework of human alveoli."Anat Rec. 258. 34-38 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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