2001 Fiscal Year Final Research Report Summary
Xenogeneic per fusion experiment and treatment for patients with liver failure using a non woven fabric bioreactor.
| Project/Area Number |
11357010
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
General surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MAKUUCHI Masatoshi The University of Tokyo, Department of Surgery, Professor, 医学部・附属病院, 教授 (60114641)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Yasuyuki The University of Tokyo, Industrial Institute for Science, Assist. Professor, 生産技術研究所, 助教授 (00235128)
NARUSE Katsutoshi The University of Tokyo, Department of Surgery, Medical staff, 医学部・附属病院, 助手 (50291323)
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| Project Period (FY) |
1999 – 2001
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| Keywords | Hybrid bioartificial liver / A non woven fabric bioreactor / porcine hepatocyte / Direct hemoperfusion treatment |
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| Research Abstract |
We developed a new system of xenogeneic direct hemoperfusion of bioartificial liver support consisting of a leukocyte adsorbent, an immunoglobulin adsorbent, and a substitute unit for hepatic function, that is, whole liver or bioreactor. A further improvement of our system by incorporating a leukocytapheresis (LCAP) device to return the leukocyte-rich portion of the per fused blood back to the patient's body directly was undergone. Influx of porcine endogenous retrovirus (PERV) into the human body has been a controvertial subject. We developed resusciteting separated plasma per fusion method, which are promising in that the patient's circuit and the bioartificial liver circuit are separated by a semipermiable membrane, which can prevent any kind of virus from flowing into the patient's circuit.
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