2002 Fiscal Year Final Research Report Summary
Prevention of liver metastasis after resection of colorecatal cancer using immunoconjugates composed of anticancer drug and chimeric antibody
| Project/Area Number |
11470260
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Japanese Foundation for Cancer Research (2000-2002)
Kyoto Prefectural University of Medicine (1999) |
|---|
Principal Investigator |
YAMAGUCHI Toshiharu Japanese Foundation for Cancer Research, Research Fellow, 癌研究所, 研究員 (90111327)
|
|---|
| Project Period (FY) |
1999 – 2002
|
| Keywords | Chimeric Antibody / Photosensitve Substances / Metastasis / Photodynamic Therapy / Gastric Cancer / Immunoconjugate / Targeting Therapy / Experimental Model |
|---|
| Research Abstract |
Stability of the immunoconjugate had been examined both in the room temperature and freezer. Drug activity and antibody activity were perfectly reserved at least 12 months in the freezer. The safety of the chimeric antibody part of the immunoconjugate chA7-NCS could not be confirmed yet. The phase I clinical study to evaluate the maximum tolerant dose of the immunoconjugate , human immune reaction, and biodistribution of the conjugate could not be finished. Next step of this project should be the phase I clinical study of immunoconjugate.
|
-
-
-
-
-
-
-
-
-
-
-
-
[Publications] Yamaguchi.T., Nakajima , T. ,Ohyama,S, ,Ohta,K. ,M atsubara ,T. ,Ueno , M. ,Ya mamoto J. , Muto ,T.: "How to prevent recurrence of scirrhous gastric cancer"Surgical Therapy. 86. 1081-1086 (2002)
Description
「研究成果報告書概要(欧文)」より
-
[Publications] Y amasuchi. T. ,NakaJima , T. ,Ohyama,S. ,Ohta,K. ,M atsubara,T. ,Ueno ,M. ,Ya mamoto J. , Muto ,T.: "Reconstruction after gastrectomy- comparison of Billroth I method and Billroth II method."Gastroent erological Surgery. 25. 35-39 (2002)
Description
「研究成果報告書概要(欧文)」より
-
