2000 Fiscal Year Final Research Report Summary
Protective Effect of New Enteral Nutritional Formula including Whey Protein Hydrolysate against Indomethacin-Induced Ulceration in Rats
| Project/Area Number |
11470264
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokai University |
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Principal Investigator |
NAKASAKI Hisao Tokai Univ.School of Medicine, Associate Prof., 医学部, 助教授 (10056145)
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| Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Tokitaka Tokai Univ.School of Medicine, Assistant Researcher, 医学部, 助手 (40214332)
TSUDA Michio Tokai Univ.School of Medicine, Associate Prof., 医学部, 助教授 (00102848)
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| Project Period (FY) |
1999 – 2000
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| Keywords | whey protein hydrolysate / enteral nutrition / rats / indomethacin-induced ulcers / anti-ulcer properties |
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| Research Abstract |
A new enteral nutritional formula containing whey protein hydrolysate (WPH) was evaluated its suppressive effect on indomethacin-induced ulcers. The first experiment resulted less intestinal ulcers appearance (1/7) in Sprague-Dawley male rats which received subcutaneous indomethacin administration or WPH formula feeding period than in those fed the formulas containing amino acids(4/6) and intact protein (6/7) as nitrogen source. In the second experiment, rats were cross-fed on different formulas, less intestinal ulcers appeared in rats pre-fed WPH formula. (1/7 in pre WPH- post WPH, 1/8 in WPH-AA, 6/7 in AA-WPH, 5/7 in AA-AA). Similar results were also shown in cecum ulcers. These results suggest that the WPH formula would have some property suppressing indomethacin-induced ulcers.
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