2001 Fiscal Year Final Research Report Summary
Factors affecting human placental transfer of anesthesia-related drugs.
| Project/Area Number |
11470330
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | HYOGO COLLEGE OF MEDICINE |
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Principal Investigator |
TASHIRO Chikara Hyogo College of Medicine, Professor, 医学部, 教授 (20107048)
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| Co-Investigator(Kenkyū-buntansha) |
TSUJIMOTO Saburo Hyogo College of Medicine, Assistant Professor, 医学部, 講師 (00144254)
MURAKAWA Kazushige Hyogo College of Medicine, Professor, 医学部, 教授 (70104263)
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| Project Period (FY) |
1999 – 2001
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| Keywords | Placental transfer / placental perfusion / propofol / p-glycoproteion / pharmacokinetics / 薬効動態 |
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| Research Abstract |
Placental transfer of porpofol in human dually per fused cotyledon in vitro.
We investigated the effects of uterine and umbilical blood flow and albumin concentration (protein binding) on the placental transfer ofpropofol by using the dually per fused human placental cityledon(single pass mode). Placental transfer was evaluated on the basis ofplacental clearaces at various flow rates or albumin concentrations of maternal and fetal perfusates. Antipyrine was added to the maternal perfusate as a reference. As results, (l) With increasing albumin concentrations of the fetal perfusate at constant maternal albumin level, propofol concentrations of fetal perfusate and its clearance were increased while both unbound propofol concentration and antipyrine clearance were unchaged. (2) With increasing albumin concentrations of maternal perfusate, propofol concentration of fetal outflow and placental clearance were decreased. (3) With increasing maternal blood flow, the propofol concentration of fetal out flow was increased while both clearance ofpropofol and antipyrine were increased (clearance ratio was constant). (4) With increasing fetal blood flow, the propofol concentration of fetal out flow was unchanged while clearance of propofol was flow-dependency increased but clearance of antipyrine showed ceiling.(5) Propofol significantly partitioned to placental tissues and the placenta would act as a condenser.In summary, our model could exactly denote the placental transfer of drug using the parameter of clearance while traditional determination of maternal and fetal blood concentration (F/M ratio) was extremely influenced with uterine blood flow, umbilival blood flow, and protein binding in maternal and umbilical blood
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