2000 Fiscal Year Final Research Report Summary
Morphological survey of Prolactin Releasing Peptide (PrRP) and PrRP receptor with special reference to functional roles of PrRP in the brain
| Project/Area Number |
11480240
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IBATA Yasuhiko Kyoto Prefectural University of Medicine, President, 学長 (10079684)
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| Co-Investigator(Kenkyū-buntansha) |
KITADA Chieko Takeda Chemical Industries, LTD, Research Manager, 医薬開拓研究本部, リサーチ・マネージャー
IIJIMA Norio Kyoto Prefectural University of Medicine, Research associate, 医学部, 助手 (00285248)
TANAKA Masaki Kyoto Prefectural University of Medicine, Associate professor, 医学部, 助教授 (80264753)
HINUMA Shuji Takeda Chemical Industries, LTD, Research Head, 医薬開拓研究本部, 主席研究員
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| Project Period (FY) |
1999 – 2000
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| Keywords | PrRP / in situ hybridization / immunohistochemistry / projection / neuroendocrinology / estrogen / progesteron / somatostatin |
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| Research Abstract |
1 PrRP-immunoreactive nerve fibers and terminals were located in the vicinity of the somatostatin(SOM)-neurons in the hypothalamic periventricular nucleus (PerVN). Some parts of SOM-neurons in the PerVN expressed PrRP receptor mRNA. Intracerebroventricular administration of PrRP decreased plasma Growth Hormone levels. From these finding it was suggested that SOM-neurons respond to PrRP and secreted SOM into the portal vessel and thus inhibit GH secretion from the anterior pituitary.
2 PrRP gene expression is regulated by gonadal steroid hormones in the medulla oblongata, and parts of PrRP synthesizing neurons are considered to be directly influenced by estrogen.
3 PrRP mRNA was expressed in the nucleus of solitary tract at embryonic day 18,on the other hand, PrRP mRNA in the hypothalamus was first expressed at postnatal day 13.
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