2001 Fiscal Year Final Research Report Summary
The role of Klotho in allograft vascular disease
| Project/Area Number |
11671304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Gunma University School of Medicine |
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Principal Investigator |
TAKAHASHI Toru Gunma Univ. Sch. of Med., Prof. Assistant, 医学部, 助手 (20292584)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Ryozo Tokyo Univ. Sch. of Med., Prof., 医学部, 教授 (60207975)
MORISHITA Yasuo Gunma Univ. Sch. of Med., Prof., 医学部, 教授 (40145470)
SATO Yasushi Gunma Univ. Sch. of Med., Prof. Assistant, 医学部, 助手 (80323351)
KURABAYASHI Masahiko Gunma Univ. Sch. of Med., Prof., 医学部, 教授 (00215047)
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| Project Period (FY) |
1999 – 2001
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| Keywords | BTEB2 / Klotho / Vascular Intimal Hyperplasia / Smooth Muscle Cells / Zn-finger Transcription Factor / Anastomotic Stricture / Restenosis after PTCA / Chronic rejection in Allograft |
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| Research Abstract |
The objective of this study is to investigate the role of klotho, which could be involved the phenotypic modulation of vascular SMCs. At first, we had to determine the molecular mechanisms of smooth muscle proliferation. We have recently identified basic transcription factor binding protein 2 (BTEB2), and hypothesized that BTEB2 might play an important role in stimulating SMC proliferation. We investigated the expression of BTEB2 in the development of restenosis after percutaneous transluminal coronary angioplasty (PTCA), the allograft vascular disease and the anastomotic stricture. Immunohistochemical analysis demonstrated that BTEB2 was expressed not only in SMCs but also in macrophage/monocytes. BTEB2 expression increased accompanying the time course of vascular stenosis. The induced expression of BTEB2 may play an important role in the development of restenosis after PTCA, the allograft vascular disease and the anastomotic stricture by stimulating SMC proliferation and activation of macrophage.
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[Publications] Toshiro Ogata T, Masahiko Kurabayashi, Yo-ichi Hoshino, Keiko Kawai-Kowase, Akio Ohtaki, Toshiharu Yamagishi, Hisao Kumakura, Susumu Ishikawa, Yasuo Morishita, Ryozo Nagai: "Inducible expression of BTEB2, a zinc finger transcription factor, at the vascular constriction. -Immunohistochemical analysis-"J Jpn Coll Angiol 41. 451-456 (2001)
Description
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