2001 Fiscal Year Final Research Report Summary
Induction of donor-specific tolerance in the model of valaed homograft transantation
| Project/Area Number |
11671343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tokyo Woman's Medical University |
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Principal Investigator |
HIRAMATSU Takeshi School of medicine, Tokyo Woman's Medical University, Asistant, 医学部, 助手 (70221520)
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| Co-Investigator(Kenkyū-buntansha) |
IMUN Tei School of medicine, Tokyo Woman's Medical University, Asistant, 医学部, 助手 (90266768)
TAKIGUTI Makoto School of medicine, Tokyo Woman's Medical University, Asistant, 医学部, 助手 (00266769)
IMAI Yasuharu School of medicine, Tokyo Woman's Medical University, Professor, 医学部, 教授 (30075246)
OKAMURA Tohru School of medicine, Tokyo Woman's Medical University, Asistant, 医学部, 助手 (20277198)
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| Project Period (FY) |
1999 – 2001
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| Keywords | homograft / intimal cell / rejection / immunosuppressant / bone marrow cell / immunological tolerance / intimal hyperplasia / calcification |
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| Research Abstract |
Reoperation was mandatory due to calcification and conduit. stenosis several years after RasteIli-type procedure for congenital heart disease in which homograft was used as RV-PA bypass. The homograft in the pediatric cases was reported to be more easily calcified compared with the adult cases. Although immunosuppressants were *administrated postoperatively in order to prevent the immuno-reaction between donor and recipient and to reduce calcification in some institutes in US, an exact mechanism of intimal hyperplasia was still unclear. In 1999, an experimental model of homograft transplantation was established using rats aorta and the donor-derived intimal cells in the homograft was confirmed to be replaced to the recipient-derived intimal cells 6-8 weeks after transplantation. In 2000, the effects of cyclosporine administration were examined, which revealed to reduce the intimal hyperplasia in the cyclosporine group postoperatively. In 2001, the effects of intrathymic inoculation of the donor-bone marrow s cells during the recipient s newborn period were examined, which showed to reduce the intimal hyperplasia in the inoculation group. From all results of these studies, the possibility to reduce the intimal hyperplasia and to prolong the reoperation was suggested by the combination of intrathymic inoculation and postoperative administration of immunosuppressants.
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