2000 Fiscal Year Final Research Report Summary
Investigation of cancer growth factors in hormone refractory prostate cancer.
| Project/Area Number |
11671585
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
KIMURA Go Nippon Medical School, Dept. of Urology, Associate Professor, 医学部, 助教授 (20234354)
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| Co-Investigator(Kenkyū-buntansha) |
KONDO Yukihiro Nippon Medical School, Dept. of Urology, Associate Professor, 医学部, 助教授 (80215467)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Prostate cancer / growth factor / androgen / hormone refractory |
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| Research Abstract |
1. The examination of prostata specific antigen (PSA) molecular form and pathological characteristics in the prostatic cancer patient.
There is the usefulness of serum PSA (total) in the diagnosis of the prostatic cancer. We examined PSA molecular form such as free PSA or free/total PSA ratio connective (PSA-ACT) to α 1-antichymotrypsin in prostate cancer. The usefulness of adjusted for PSA with prostate gland volume or transition zone volume Density (PSAD) or the transition zone volume (PSATZD) is also examined. The correlation was recognized at adjusted for the transition zone volume (PSATZD).
2. The examination of prostate gland conversion division volume and pathological characteristics in the prostatic cancer patient.
Then, the inverse correlation relation was recognized in volume and Gleason score in the conversion division, when prostate gland total extirpation sample and conversion division volume on the ultrasonic wave in the biopsy and Gleason score were examined.
3. The examination in the prostatic cancer in operation sample of growth factor.
The localization and dyeability were contrasted with the histopathological image of prostatic cancer by doing the immune tissue dyeing using the growth factor antibody including growth factor that it is the insulin in prostate gland total extirpation sample. It tended to do low intensity of each growth factor in carcinoma tissue and the circumference the result which the prostate gland conversion division volume was big as the result, and there was. The possibility of working unlike the growth factor of cancer cell rather inhibitory was indicated the factor which increased the conversion division volume from the above result.
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[Publications] Kondo, Y., Yanagiya, T., Himeno, S., Yamabe, Y., Schwartz, D., Akimoto, M., Lazo, J.S.and Imura, N.: "Simian virus 40-transformed metallothionein null cells showed increased sensitivity to cadmium but not to zinc, copper, mercury or nickel."Life Science. 64. 145-150 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] Nemoto, K., Kondo, Y., Himeno, S., Suzuki, Y.Hara, S., Akimoto, M and Imura, N.: "Modulation of telomerase activity by zinc in human prostatic and renal cancer cells."Biochemical Pharmacolgy. 59. 401-405 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] Kondo, Y., Himeno, S., Endo, W., Mita, M., Suzuki, Y., Nemoto, K., Akimoto, M., Lazo, J.S.and Imura, N.: "Metallothionein modulates the carcinogenicity of N-butyl-N-(4-hydroxybutyl) nitrosamine in mice."Carcinogenesis. 20. 1625-1628 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] Hattori, T., Kimura, G., Horiuch, K., Tsuboi, N., Yoshida, K.and Akimoto, M.: "The efficacy of Bacillus Calmette Guerin instillation therapy of the upper urinary tract for carcinoma in situ."International Journal of Clinical Oncology. 4. 295-297 (1999)
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[Publications] Watari, Y., Stoh, H., Matsubara, M., Asakawa, K., Kamaguchi, H., Nagai, S., Murase, Y., Yokoyama, M., Kimura, G., Tamura, K.and Sugisaki, Y.: "Comparison of urine cytology between the ileal conduit and Indiana pouch."Acta.Cytologia. 44. 748-751 (2000)
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「研究成果報告書概要(欧文)」より
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