2000 Fiscal Year Final Research Report Summary

Study of the effects of bisphenol A in the dental pulp tissue

Research Project

Project/Area Number	11671901
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Conservative dentistry
Research Institution	Meikai university
Principal Investigator	KATAYAMA Tadashi Mikai unversity, School of Dentsitry, Professor, 歯学部, 教授 (10105596)
Co-Investigator(Kenkyū-buntansha)	YOKOSE Satoshi Mikai Unversity, school of Dentisry, Assistant Professor, 歯学部, 助教授 (90245803)
Project Period (FY)	1999 – 2000
Keywords	Bisphenol A / Dental pulp tissue / HPLC / Mouse
Research Abstract	In order to examine the amount of bisphenol A (BPA) taken in the dental pulp tissues of mouse after peritoneal injection, we performed the HPLC analysis in the homogenized dental pulp tissues. The eight weeks old male mice were peritoneally injected BPA (100 μg/g body weight), and the dental pulp tissues were extracted from lower incisors after half and one hour of the injection, respectively. Then serums were also collected to analyze the amount of BPA. The BPA levels of the dental pulp tissues indicated 100μg/g after half hour of the injection, and the levels were kept for one hour after the injection. On the other hand, serum levers of BPA reached to 1μg/μl after half hour of the injection and the levels were kept for one hour after the injection. These results suggest that BPA is taken in the dental pulp tissue throughout the blood system and may be accumulated in the dental pulp tissue.

(4 results)