2000 Fiscal Year Final Research Report Summary
Optical study of neural-complex adaptive systems
| Project/Area Number |
11694252
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SAKAI Tetsuro Tokyo Medical and Dental University. Graduate School. Associate professor, 大学院・医歯学総合研究科, 助教授 (40153845)
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| Co-Investigator(Kenkyū-buntansha) |
SATO Katsushige Tokyo Medical and Dental University. Graduate School. Assistant professor, 大学院・医歯学総合研究科, 助手 (80291342)
MOMOSE-SATO Yoko Tokyo Medical and Dental University. Graduate School. Lecturer, 大学院・医歯学総合研究科, 講師 (70251501)
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| Project Period (FY) |
1999 – 2000
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| Keywords | coplexity / distributing system / voltage-sensitive dye / optical recording / imaging / chisk embryo / rat / vervous system |
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| Research Abstract |
The purpose of this study is to characterize the integrative properties of the neuronal systems that are distributed, rather than those which are properties of individual cells. We will specifically focus on those properties which relate to interactions among the component neurons. The technology best suited for carrying out these studies is multiple-site optical recording using voltage-sensitive dyes, which can provide high resolution (temporal and spatial) views of neuronal activity throughout a nervous system. The proposed experiments take advantage of the special expertise, facilities, and different preparations used in the laboratories of the group in order to identify basic principles by which networks integrate neuronal information. "Distributed processing" has been used to label several phenomena. First, it can refer to instances where large numbers of neurons in one or several regions (ganglia) of a central nervous system are involved in generating each behavior. Second, it may refer to situations where individual neurons are multifunctional : each cell is involved in the discrimination of more than one sensory input or the generation of more than one behavioral output. Third, distributed processing refers to situations where synaptic strengths of the connections between neurons are low and activity in many excitory and inhibitory inputs are evaluated in determining the output of each individual neuron. The experiments in this study examined all three aspects of the distributed processing.
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[Publications] Momose-Sato, Y., Komuro, H., Hirota, A., Sakai, T., Sato, K., and Kamino, K.: "Optical imaging of spatiotemporal patterning of neural responses in the embryonic chick superior cervical ganglion"Neuroscience. 90. 1069-1083 (1999)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Momose-Sato, Y., Sato, K., Arai, Y., Yazawa, I., Mochida, H.and Kamino, K.: "Evaluation of voltage-sensitive dyes for monitoring for long-term recording of neural activity in the hippocampus."Journal of Memorane Biology. 172. 145-157 (1999)
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[Publications] Sato, K., Yazawa, I., Mochida, H., Sasaki, S., Kamino, K.and Momose-Sato, Y.: "Optical detection of embryogenetic expression of vagal excitability in the rat brain stem."Neuroreport. 11. 3759-3763 (2000)
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「研究成果報告書概要(欧文)」より
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[Publications] Sato, K., Mochida, H., Sasaki, S., Yazawa, I., Kamino, K.and Momose-Sato, Y.: "Optical responses to micro-application of GABA agonists in the embryonic chick brain stem."Neuroreport. 12. 95-98 (2001)
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[Publications] Momose-Sato, Y., Sato, K., Mochida, H., Yazawa, I., Sasaki, S.and Kamino, K.: "Spreading depolarization waves triggered by vagal stimulation in the embryonic chick brain : optical evidence for intercellular communication in the developing CNS."Neuroscience. (in press). (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Mochida, H., Sato, K., Sasaki, S., Yazawa, I., Kamino, K.and Momose-Sato, Y.: "Effects of anisomycin on LTP in the hippocampal CA1 : Long-term analysis using optical recording."Neuroreport. (in press). (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Mochida, H., Sato, K., Arai, Y., Sasaki, S., Itaru, Y., Kamino, K.and Momose-Sato, Y.: "Multiple-site optical recording reveals embryonic organization of synaptic networks in the chick spinal cord."European Journal of Neuroscience. (in press). (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Yazawa, I., Sasaki, S., Mochida, H., Kamino, K., Momose-Sato, Y.and Sato, K.: "Developmental changes in trial-to-trial variations in whisker barrel responses studied using intrinsic optical imaging : Comparison between normal and de-whiskered rats."Journal of Neurophysiology. (in press). (2001)
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「研究成果報告書概要(欧文)」より
