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2005 Fiscal Year Final Research Report Summary

Genomic analysis on genetic factors of human diseases and elucidation of their molecular mechanisms

Research Project

Project/Area Number 12203002
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

SUGANO Sumio  The University of Tokyo, Graduate School of Frontier Sciences, PROFESSOR, 大学院新領域創成科学研究科, 教授 (60162848)

Co-Investigator(Kenkyū-buntansha) HATA Akira  CHIBA UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院医科学研究院, 教授 (00244541)
MIKI Tetsuro  EHIME UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 医学部, 教授 (00174003)
TOKUNAGA Katsushi  THE UNIVERSITY OF TOKYO, GRADUATE SCHOOL OF MEDICINE, PROFESSOR, 大学院医学系研究科, 教授 (40163977)
NIIKAWA Norio  NAGASAK UNIVERSITY, GRADUATE SCHOOL OF BIOMEDICAL SCIENCE, PROFESSOR, 大学院医歯薬学総合研究科, 教授 (00111170)
MAEDA Tadakazu  KITAZATO UNIVERSITY, GRADUATE SCHOOL OF SCIENCE, PROFESSOR, 理学部, 教授 (90265728)
Project Period (FY) 2000 – 2005
KeywordsAllergic asthma / A genome / circulatory organ / high blood pressure / Diabetes
Research Abstract

We held an international symposium "The Impact of the Genome Science for the Future Medicine" and a public forum "Genome Science and Society" from January 17^<th> to January 21^<st>, 2006 co-sponsoring with JSPS Research For the Future Program (RFFP: ended at the fiscal year of 2004) and Grant-in-Aid for Scientific Research on Priority Areas "Applied Genomics" (2004-2009). The speakers of the international symposium were 5 from JSPS RFFP, 6 from this program, 3 from "Applied Genomics" and 9 from abroad. For the public forum, Mr Yoichro Murakami gave the Key note speech and there were 6 scientific sessions and panel discussions by the speakers. We got about 550 participants.
We also held a symposium for general public entitled "What does Genome determine and How? : Towards the understanding of the life as a system" in January 18^<th> and 19^<th>, 2006 with the co-sponsor of all 4 of the Grant-in-Aid for Scientific Research on Priority Areas related genome science ( "Integrated Genome", "Medical Genome Science", "Genome Biology", "Genome Informatics"). This symposium consisted of 3 sessions and one panel discussion: Session1: "Genome to Cell" (Chair: Dr. Toshihisa Takagi, with 4 Speakers), Session2: "Genome to Complex Living Functions" (Chair: Dr. Sumio Sugano with 6 Speakers), Session3: "Genome to Human" (Chair: Dr. Naotake Ogasawara with 7 Speakers). The speakers on the panel discussion were Drs Takashi Kadowaki, Naotake Ogasawara, Hideko Urusihara, Asao Fujiyama, Toshihisa Takagi and Kazuto Kato and chaired by Dr. Yuji Kohara. There were about 700 participants. We made final report for our Grant-in-Aid for Scientific Research on Priority Areas Program.

  • Research Products

    (43 results)

All 2005 2004 2003 2002 2001 2000

All Journal Article (42 results) Book (1 results)

  • [Journal Article] 15'SAGE : 5'-end Serial Analysis of Gene Expression database.2005

    • Author(s)
      Kasai Y, et al.
    • Journal Title

      Nucleic Acids Res. 33

      Pages: D550-D552

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The genome of the social amoeba Dictyostelium discoideum.2005

    • Author(s)
      Eichinger L, et al.
    • Journal Title

      Nature 435

      Pages: 43-57

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Substitution Rate and Structural Divergence of 5'UTR Evolution : Comparative Analysis Between Human and Cynomolgus Monkey cDNAs.2005

    • Author(s)
      Osada N, et al.
    • Journal Title

      Mol Biol Evol. 22

      Pages: 1976-1982

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] dbQSNF : a database of SNPs in human promoter regions with allele frequency information determined by single-strand conformation polymorphism-based methods.2005

    • Author(s)
      Tahira T, et al.
    • Journal Title

      Hum Mutat. 226

      Pages: 69-77

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cell surface labeling and mass spectrometry reveal diversity of cell-surface markers and signaling molecules expressed in undifferentiated mouse embryonic stem cells.2005

    • Author(s)
      Nunomura K, et al.
    • Journal Title

      Mol Cell Proteomics. 4

      Pages: 1968-1976

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 5'SAGE : 5'-end Serial Analysis of Gene Expression database.2005

    • Author(s)
      Kasai Y, et al.
    • Journal Title

      Nucleic Acids Res. 33

      Pages: D550-D552

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The genome of the social amoeba Dictyostelium discoideum2005

    • Author(s)
      Eichinger L, et al.
    • Journal Title

      Nature. 435

      Pages: 43-57

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genome-wide analysis reveals strong correlation between CpG islands with nearby transcription start sites of genes and their tissue specificity.2005

    • Author(s)
      Yamashita R, et al.
    • Journal Title

      Gene. 350

      Pages: 129-136

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] dbQSNP : a database of SNPs in human promoter regions with allele frequency information determined by single-strand conformation polymorphism-based methods.2005

    • Author(s)
      Tahira T., et al.
    • Journal Title

      Hum Mutat. 226

      Pages: 69-77

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Complete sequencing and characterization of 21,243 full-length human cDNAs.2004

    • Author(s)
      Ota T, et al.
    • Journal Title

      Nat Genet. 36

      Pages: 40-45

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Full-malaria 2004 : an enlarged database for comparative studies of full-length cDNAs of malaria parasites, Plasmodium species.2004

    • Author(s)
      Watanabe, J., et al.
    • Journal Title

      Nucleic Acids Res. 32

      Pages: D334-D338

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] DBTSS, DataBase of Transcriptional Start Sites : progress report 2004.2004

    • Author(s)
      Suzuki, Y., et al.
    • Journal Title

      Nucleic Acids Res. 32

      Pages: D78-D81

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 5'-end SAGE for the analysis of transcriptional start sites.2004

    • Author(s)
      Hashimoto SI., et al.
    • Journal Title

      Nat Biotechnol. 22

      Pages: 1146-1149

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Analysis of small human proteins reveals the translation of upstream open reading frames of mRNAs.2004

    • Author(s)
      Oyama M, et al.
    • Journal Title

      Genome Res. 10B

      Pages: 2048-2052

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.2004

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      Genome Res. 14

      Pages: 1711-1718

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Promoter prediction analysis on the whole human genome.2004

    • Author(s)
      Bajic VB, et al.
    • Journal Title

      Nat Biotechnol. 22

      Pages: 1467-1473

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 5'-end SAGE for the analysis of transcriptional start sites.2004

    • Author(s)
      Hashimoto SI, et al.
    • Journal Title

      Nat Biotechnol. 22

      Pages: 1146-1149

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Construction of a full-length enriched and a 5'-end enriched cDNA library using the oligo-capping method.2003

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      Methods Mol Biol. 221

      Pages: 73-91

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Analysis of 5'-end sequences of chimpanzee cDNAs.2003

    • Author(s)
      Sakate R, et al.
    • Journal Title

      Genome Res. 13

      Pages: 1022-1026

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.2003

    • Author(s)
      Matsuda A, et al.
    • Journal Title

      Oncogene. 22

      Pages: 3307-3318

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The 5' terminal oligopyrimidine tract of human elongation factor 1A-1 gene functions as a transcriptional initiator and produces a variable number of Us at the transcriptional level.2003

    • Author(s)
      Shibui-Nihei A et al.
    • Journal Title

      Gene. 311

      Pages: 137-145

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice.2003

    • Author(s)
      Kikuchi S. et al.
    • Journal Title

      Science. 301

      Pages: 376-379

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas : identification of 305 genes differentially expressed between favorable and unfavorable subsets.2003

    • Author(s)
      Ohira M, et al.
    • Journal Title

      Oncogene 22

      Pages: 5525-5536

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Small open reading frames in 5' untranslated regions of mRnas.2003

    • Author(s)
      Yamashita R, et al.
    • Journal Title

      C R Biol. 326

      Pages: 987-991

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The 5' terminal oligopyrimidine tract of human elongation factor 1A-1 gene functions as a transcriptional initiator and produces a variable number of Us at the transcriptional level.2003

    • Author(s)
      Shibui-Nihei A, et al.
    • Journal Title

      Gene. 311

      Pages: 137-45

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas : identification of305 genes differentially expressed between favorable and unfavorable subsets.2003

    • Author(s)
      Ohira M, et al.
    • Journal Title

      Oncogene. 22

      Pages: 5525-5536

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Analysis of transcriptomes of human malaria parasite Plasmodium falciparum using full-length enriched library : identification of novel genes and diverse transcription start sites of messenger RNAs.2002

    • Author(s)
      Watanabe J, et al.
    • Journal Title

      Gene. 291

      Pages: 105-113

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain.2002

    • Author(s)
      Omori Y, et al.
    • Journal Title

      Biochem Biophys Res Commun. 293

      Pages: 470-477

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Search for genes positively selected during primate evolution by 5'-end-sequence screening of cynomolgus monkey cDNAs.2002

    • Author(s)
      Osada N, et al.
    • Journal Title

      Genomics. 79

      Pages: 657-662

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] DBTSS : DataBase of human Transcriptional Start Sites and full-length cDNAs.2002

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      Nucleic Acids Res. 30

      Pages: 328-331

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A Transcription Factor Response Element for Gene Expression During Circadian Night.2002

    • Author(s)
      Ueda R.H, et al.
    • Journal Title

      Nature 418

      Pages: 534-539

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular cloning, mRNA expression and chromosomal localization of mouse angiotensin-converting enzyme-related carboxypeptidase (mACE2).2002

    • Author(s)
      Komatsu T, et al.
    • Journal Title

      DNA Seq. 13

      Pages: 217-220

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A Transcription Factor Response Element for Gene Expression During Circadian Night.2002

    • Author(s)
      Ueda R.et al.
    • Journal Title

      Nature. 418

      Pages: 534-539

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] HUNT : launch of a full-length cDNA database from the helix research institute.2001

    • Author(s)
      Yudate, H.T., et al.
    • Journal Title

      Nucl. Acid Res. 29

      Pages: 185-188

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Identification and characterization of the potential promoter regions of 1031 kinds of human genes.2001

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      Genome Res. 11

      Pages: 677-684

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites.2001

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      EMBO Rep. 2

      Pages: 388-393

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Construction of full-length-enriched cDNA libraries. The oligo-capping method.2001

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      Methods Mol Biol. 175

      Pages: 143-153

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Diverse transcriptional initiation revealed by fine, large-scale mapping of mRNA start sites2001

    • Author(s)
      Suzuki Y, et al.
    • Journal Title

      EMBO Rep. 2

      Pages: 388-393

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Statistical analysis of 5' untranslated region of human mRNA using "Oligo-capping" cDNA libraries.2000

    • Author(s)
      Suzuki, Y., et al.
    • Journal Title

      Genomis 64

      Pages: 286-297

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Comparative PCR : A Simple and Sensitive Method to Quantify Low-Abundant mRNA Species.2000

    • Author(s)
      Ohmori, Y., et al.
    • Journal Title

      Genomics 67

      Pages: 140-145

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Statistical analysis of 5' untranslated region of human mRNA using "Oligo-capping" cDNA libraries.2000

    • Author(s)
      Suzuki, Y, et al.
    • Journal Title

      Genomis 64

      Pages: 286-297

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Comparative PCR : A Simple and Sensitive Method to Quantify Low-Abundant mRNA Species.2000

    • Author(s)
      Ohmori, Y, et al.
    • Journal Title

      Genomics 67

      Pages: 140-145

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Methods Mol Biol. (221)2003

    • Author(s)
      Suzuki Y
    • Total Pages
      73・91
    • Publisher
      Construction of a full-length enriched and a 5'-end enriched cDNA library using the oligo-cappping method
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2008-05-27  

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