2005 Fiscal Year Final Research Report Summary
Advanced Brain Science Project
| Project/Area Number |
12209001
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Tokyo |
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Principal Investigator |
IHARA Yasuo Univ.Tokyo, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (60114386)
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| Co-Investigator(Kenkyū-buntansha) |
MASU Masayuki Univ. Tsukuba, Grad.Sch Compo.Human Sci., Professor, 大学院人間総合科学研究科, 教授 (20243032)
TSUMOTO Tadaharu Univ. Osaka, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (50028619)
TSUJI Shoji University of Tokyo, Graduate School of Medicine, Professor, 医学部附属病院, 教授 (70150612)
TANJI Jun Tohoku Univ., Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (10001885)
ARAI Hiroyuki Tohoku Univ., Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (30261613)
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| Project Period (FY) |
2000 – 2005
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| Keywords | Neurogenesis / Guidance molecules / BDNF and visual center / Alzheimer's disease / Spinal and bulbar muscular atrophy / Polyglutamine diseases / Higher cortical function / Plasticity of the neuron |
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| Research Abstract |
By this project, many papers with the highest impact have been published, which have clearly shown that the level of neuroscience in Japan is very high. When the project was initiated in 2000, goals were set for each field, and I believe all of us have reached them. Among the excellent publications, the following ones are exceptional: "Brain repair" by Dr. M. Nakafuku; identification of guidance molecules by Dr. K. Kaibuchi, discovery of neprilysin as a AB-degrading protease by Dr. T. Saido, and clinical trial of a new drug for X-linked spinal and bulbar muscular atrophy by Dr. G. Sobue. In addition, steady progress in the research of higher cortical function using monkey by Dr. J. Tanji should be mentioned here. Finally, identification of one susceptibility gene for Alzheimer's disease is a milestone in this kind of research in Japan.
It is often claimed that interdisciplinary interaction is required to significantly advance science, and indeed this project provided such opportunity. This can partly explain why A01 investigators have obtained the most striking data: excellent investigators majoring development in general, neurobiology and stem cells have got together under the flag of neurogenesis, and heavily interacted with each another.
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[Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein with a potential role as a nucleotide repair protein2004
Author(s)
Sano Y, Date H, Igarashi S, Onodera O, Oyake M, Takahashi T, Hayashi S, Morimatsu M, Takahashi H, Makifuchi T, Fukuhara N, Tsuji S
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Journal Title
Ann Neurol 55
Pages: 241-249
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein with a potential role as a nucleotide repair protein.2004
Author(s)
Sano Y, Date H, Igarashi S, Onodera O, Oyake M, Takahashi T, Hayashi S, Morimatsu M, Takahashi H, Makifuchi T, Fukuhara N, Tsuji S
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Journal Title
Ann.Neurol. 55
Pages: 241-249
Description
「研究成果報告書概要(欧文)」より
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