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2002 Fiscal Year Final Research Report Summary

Analysis and imaging of arrhythmia electrophysiological phenomena in the heart by modeling and experimental investigation of them

Research Project

Project/Area Number 12308046
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionThe University of Tokyo

Principal Investigator

INADA Hiroshi  Graduate School of Engineering, Professor, 大学院・工学系研究科, 教授 (20028393)

Co-Investigator(Kenkyū-buntansha) NAKAZAWA Kazuo  National Cardiovascular Center, Research Institute, Manager(Researcher), 研究所, 室長(研究職) (50198058)
KODAMA Itso  Nagoya University, Research Institute of Environmental Medicine, Professor, 環境医学研究所, 教授 (30124720)
SAKUMA Ichiro  Graduate School of Frontier Sciences, Professor, 大学院・新領域創成科学研究科, 教授 (50178597)
Project Period (FY) 2000 – 2002
KeywordsArrhythmia / Computer simulation / Spiral reentry / LR model / Optical mapping system of myocardial action potential / Response of whole heart to electrical stimuli / Two dimensional specimen of the parfused rabbit / Dynamics of spiral reentry
Research Abstract

In the present study we applied techniques of computer simulation to analyzing propagation of cardiac excitation wave at the occurrence of arrhythmia and its related phenomena and developed a system for measuring action potential of myocardial cell membrane. Then, the following investigations were conducted in order to compare observation results of spiral reentry generated by experiments with results of the simulation. (1) Simulation by using a model of myocardial action potential and visualization of propagation of cardiac excitation : In this study, one myocardial unit was expressed by the differential equation by using LR(Luo-Rudy) model and the simulation of arrhythmias was performed with a supercomputer. Secondly, we reproduced the propagation of cardiac excitation based on the theory of spiral wave and succeeded in visualization of the propagation.c Development of a optical mapping system of myocardial action potential and investigation of responses of a whole heart to electric … More stimuli by analyzes of optical signals : We developed a high-resolution optical mapping system with two high-speed video digital cameras to observe widely membrane action potential of a heart of a Japanese white rabbit which was dyed using the voltage sensitive dye di-4-ANEPPS. The responses of the whole heart to the electric stimuh can be investigated in detail by the analyzes of optical signals with the system. (3) Analysis of the relationship between dynamics of spiral reentry and the action potential using the perfused rabbit heart as materials and investigation of function of anti-arrhythmic drugs : By using the optical mapping system, the spiral reentry of two-dimensional specimen of the perfused rabbit heart is investigated from the viewpoint of dynamics of excitation rotation and changes in the wave shape of action potential and the function of anti-arrhythmic drugs. As the results, it was revealed that the dynamics of the spiral reentry was associated with interaction of the wave fronts and the tails of excitation, anisotropy of myocardial structure and so on. Less

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Ichiro Sakuma, Hiroshi Inada, Itsuo Kodama, et al.: "Computer Simulations of Elecrical Propagation in Cardiac Tissue"Medical Physics. 27・6. (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Itsuo Kodama, Ichiro Sakuma, et al.: "Regional differences in arrhytmogenic after effects of high intensity DC stimulation in the ventricle"Pacing and Clinical Electrophysiology. 23. 807-817 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Sakuma, Itsuo Kodama, et al.: "Analysis of epicardial activation patterns during DC-shock induced ventricular tachycardia"Environmental Medicine. 44. 32-34 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Sakuma, Hiroshi Inada, Itsuo Kodama, et al.: "A high-resolution optical mapping and analysis system of action potentials during ventricular arrhythmias"Proceeding of the 3rd China-Japan-Korea Joint Symposium on Medical Informatics. 53-55 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Sakuma, Hiroshi Inada, Itsuo Kodama, et al.: "Computer simulation of reentrant spiral excitation propagation in cardiac tissue"Proceeding of the 3rd China-Japan-Korea Joint Symposium on Medical Informatics. 56-58 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Sakuma, Itsuo Kodama, et al.: "Sustained monomorphic ventricular tachycardia in the two-dimensional left ventricular epicardial sheets of rabbit hearts perfused in-vitro"Environmental Medicine. 45. 92-94 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuo Nakazawa, et al.: "Role of structural complexities of septum tissue in maintaining ventricular fibrillation in isolated, perfused canine ventricle"Journal of Cardiovascular Electrophysiology. 12(1). 66-75 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuo Nakazawa, et al.: "Breakthrough waves during ventricular fibrillation depend on the degree of rotational anisotropy and the boundary conditions"Journal of Cardiovascular Electrophysiology. 12(3). 312-322 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Sakuma, Hiroshi Inada, Kodama I, et al.: "Na+ channel blockade causes a prolongation of electrical diastole during spiral-type reentry in the ventricle"Environmental Medicine. 46. 103-105 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakazawa K, et al.: "Afterdepolarizations Promote the Transition From Ventricular Tachycardia to Fibrillation in a Three Dimensional Model of Cardiac Tissue"Circulation Journal. 66(5). 505-510 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichiro Sakuma, Hiroshi Inada, Itsuo Kodama, et.al: "Computer Simulations of Electrical Propagation in Cardiac Tissue"Medical Physics. 27-6. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itsuo Kodama, Ichiro Sakuma, et.al: "Regional differences in arrhytmogenic after effects of high intensity DC stimulation in the ventricle"Pacing and Chinical Electrophysiology. 23. 807-817 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ichiro Sakuma, Itsuo Kodama, et.al: "Analysis of epicardial activation patterns during DC-shock induced ventricular tachycardia"Environmental Medicine. 44. 32-34 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ichiro Sakuma, Hiroshi Inada, Itsuo Kodama, et.al: "A high-resolution optical mapping and analysis system of action potentials during ventricular arrhythmias"Proceeding of the 8rd China-Japan-Korea Joint Symposium on Medical Informatics. 53-55 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ichiro Sakuma, Hiroshi Inada, Itsuo Kodama, et.al: "Computer simulation of reentrant spiral excitation propagation in cardiac tissue"Proceeding of the 3rd China-Japan-Korea Joint Symposium on Medical Informatics. 56-58 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ichiro Sakuma, Itsuo Kodama, et.al: "Sustained monomorphic ventricular tachycardia in the two-dimensional left ventricular epicardial sheets of rabbit hearts perfused in-vitro"Environmental Medicine. 45. 92-94 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuo Nakazawa, et.al: "Role of structural complexities of septum tissue in maintaining ventricular fibrillation in isolated, perfused canine ventricle"Journal of Cardiovascular Electrophysiology. 12(1). 66-75 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuo Nakazawa, et.al: "Breakthrough waves during ventricular fibrillation depend on the degree of rotational anisotropy and the boundary conditions"Journal of Cardiovascular Electrophysiology. 12(3). 312-322 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ichiro Sakuma, Hiroshi Inada, Kodama, I., et.al: "Na+ channel blockade causes a prolongation of electrical diastole during spiral-type reentry in the ventricle"Environmental Medicine. 46. 103-105 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakazawa K., et.al: "Afterdepolarizations Promote the Transition From Ventricular Tachycardia to Fibrillation in a Three Dimensional Model of Cardiac Tissue"Circulation Journal. 66(5). 505-510 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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