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2002 Fiscal Year Final Research Report Summary

Approach to the cure oriented therapy for chronic renal disease by the establishment of a disease model mouse strain which shows naturally occurring nephritic syndrome

Research Project

Project/Area Number 12480252
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionOsaka University

Principal Investigator

KUROSAWA Tsutomu  Osaka University, Medical School, Associate Professor, 医学部, 助教授 (60129997)

Co-Investigator(Kenkyū-buntansha) TATSUMI Haruyuki  Sapporo Medical College, Professor, 教授 (90171719)
AGUIN Takashi  Hokkaido University, Graduate School of Veterinary, Professor, 獣医学部, 教授 (00212457)
MANABE Noboru  Kyoto University, Graduate School of Agriculture, Associate Professor, 農学部, 助教授 (80243070)
TAJIMA Masaru  Osaka University, Graduate School of Medicine, Assistant Professor, 医学部, 助手 (10227077)
OGURA Atsurou  Riken Tsukuba Institute Bio Resource Center Engineering Division Head, 遺伝工学基盤技術室, 室長(研究職) (20194524)
Project Period (FY) 2000 – 2002
KeywordsDisease model / Chronic renal disease / Disease analysis / Genetic analysis / SPF animal / Gene resources / Gene therapy / Treatment with cytokines
Research Abstract

Many of conquest of an incurable disease has been terminated by development of a suitable animal used disease models. Since the citizen of at least 200,000 or more present our countries is chronic renal disease, kidney dialysis medical treatment is received, and the number of patients which newly goes into dialysis has also become about 30,000 people every year. Although kidney dialysis is the symptomatic therapy which was extremely excellent as an internal medical-treatment of chronic renal disease, not a radical cure treatment but original kidney disease cannot be made to recover. Kidney dialysis has become the degree which shakes even the universal national health insurance system which leads to the increase in a patient, and the increase in conjointly immense medical expenses, and our country is proud of. We decided to explore the way to the radical cure medical treatment of the chronic renal disease which is one of the incurable diseases paying attention to the naturally occurring nephrosis mouse discovered by the National Institute of Infectious Disease. It strives for the establishment of animal- disease-modeling strain and its maintenance first, and two research organizations are performing strain of mouse maintenance now. Since the high disease model system of quality was maintainable in microbiology, the overseas 2 research organizations and the domestic 8 research organizations were able to be apportioned to the system. The main responsible gene was mapped on the No. 15 chromosome, and the still more detailed gene location was clarified. Because all mouse DNA sequence was released, the main part of the responsible gene of this model is also expected to be solved soon. The usefulness of this strain of mouse increased. According to the result of this research project, it is suggested that the gene therapy of cytokine is suitable for chronic renal insufficiency, and research of gene therapy is done now using this model.

  • Research Products

    (44 results)

All Other

All Publications (44 results)

  • [Publications] Mizuno, S.: "Reciprocal balance of hepatocyte growth factor and transforming growth factor-1 in renal fibrosis in mice"Kidney Int.. 57. 937-948 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizuno, S.: "Interleukin-2 (IL-2)-dependent growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IL-2"Animal Biochemistry. 36(2). 39-45 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sawashima, K.: "Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure"Am.J.Vet.Res.. 61(9). 1080-1086 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizuno-Horikawa, Y.: "Advanced Glomerulosclerosis Is Reversible in Nephrotic Mice"Biochem.Biophys.Res.Commun.. 284(3). 707-713 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizuno, S.: "Immunohistochemical Analysis of Molecular Events in Tubulo-Interstitial Fibrosis in a Mouse Model of Diffuse Mesangial Sclerosis (ICGN Strain)"J.Vet.Med.Sci.. 63(3). 299-307 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto, H.: "Microbiological Contamination in Genetically Modified Animals and Proposals for a Microbiological Test Standard for National Universities in Japan"Exp.Anim.. 50(5). 397-407 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sawashima, K.: "Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expression in unilateral ureteral obstruction"Exp.Nephrol.. 10. 7-18 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okamoto, M.: "Linkage Mapping of the Mouse Nephrosis(nep) Gene to Chromosome15"J.Vet.Med.Sci.. 63(12). 1347-1350 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamura, K.: "Characteristic changes in carbohydrate profile in the kidneys of hereditary nephrotic mice (ICGN strain)"J.Vet.Med.Sci.. 62(4). 379-390 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchio, K.: "Decreased matrix metalloproteinase activity in be kidneys of hereditary nephrotic mice (ICGN strain)"Nephron. 86. 145-151 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Manabe, N.: "Changes in quantitative profile of extracellular matrix components in the kidneys of rats with adriamycin-induced nephropathy"J.Vet.Med.Sci.. 63(2). 125-133 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamaguchi, M.: "localization of proliferative and apoptotic cells in the kidneys of ICR-derived glomerulonephritis (ICGN) mice"J.Vet.Med.Sci.. 63(7). 781-787 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchio-Yamada, K.: "Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome"J.Vet.Med.Sci.. 63(11). 1171-1178 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchio, K.: "Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts"Laboratory Investigation. 82. 619-628 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 黒澤 努: "慢性腎不全発症マウスモデルの血清生化学値の特徴"日本疾患モデル学会記録. 16. 12-12 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 黒澤 努: "慢性腎疾患の病態形成に関与するHGF、TGF-βの役割"炎症と免疫. 9(3). 87-95 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 澤嶋 功: "猫の慢性腎疾患における糸球体濾過値の低下と間質の線維化程度の相開"日獣会誌. 54. 687-691 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 黒澤 努: "マイクロアイソレーターシステム(VIC)の簡易改良について"実験動物と環境. 10(1). 53-54 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 澤嶋 功: "低蛋白食によるネコの慢性腎不全の進行抑制"日獣会誌. 55. 591-595 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamada-Uchio, K.: "Abnormalities of extracellular matrix metabolisms in the kidney of ICGN mice, a strain of mice with hereditary nephrotic syndrome"Reproductive Biotechnology : Reproductive biotechnology update and its related physiology (Hokuto Pub. Co.). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamaguchi, M.: "Renal anemia in ICR-derived glomerulonephritis (ICGN) mice"Reproductive Biotechnology : Reproductive biotechnology update and its related physiology (Hokuto Pub. Co.). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamaguchi-Yamada, M.: "Anemia associated with renal failure in the ICR-derived glomerulonephritis (ICGN) mice"Animal Frontier Science(Hokuto Pub. Co.). 364 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizuno, S.: "Inteleukin-2 (IL-2)-dependent growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IK-2"Kidney Int.. 57. 937-948 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno, S.: "Inteleukin-2 (IL-2)-dependent growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IK-2"Animal Biochemistry. 36 (2). 39-45 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawashima, K.: "Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure"Am. J. Vet. Res.. 61 (9). 1080-1086 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno-Horikawa, Y.: "Advanced Glomerulosclerosis Is Reversible in Nephrotic Mice"Biochem. Biophys. Res. Commun.. 284 (3). 707-713 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno, S.: "Immunohistochemical Analysis of Molecular Events in Tubulo-Interstitial Fibrosis in a Mouse Modal of Diffuse Mesangial Sclerosis (ICGN Strain)"J.Vet.Med.Sci.. 63 (3). 299-307 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto,H.: "Microbiological Contamination in Genetically Modified Animals and Proposals"Exp.Anim.. 50 (5). 397-407 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawashima, K.: "Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expression in unilateral ureteral obstruction"Exp.Nephrol.. 10. 7-18 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okamoto, M.: "Linkage Mapping of the Mouse Nephrosis(nep) Gene to Chromosome 15"J.Vet.Med.Sci.. 63(12). 1347-1350 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno, S.: "Interleukin-2 (IL-2)-dependemt growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IK-2"Kidney Int.. 57. 937-945 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno, S.: "Interleukin-2 (IL-2)-dependent growth of canine anti-tumor lymphocytes : Comparison of human IL-2 with homologous Dog IK-2"Animal Biochemistry. 36 (2). 39-45 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawashima, K.: "Expression of α-smooth muscle actin and fibronectin in tubulointerstitial lesions of cats with chronic renal failure"Am. J. Vet. Res.. 61 (9). 1080-1086 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno-Horikawa, Y.: "Advanced Glomerulosclerosis Is Reversible in Neplrotic Mice"Biochem. Biophys. Res. Commun.. 284 (3). 707-713 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuno, S.: "Immunohistochemical Analysis of Molecular Events in Thbulo-Interstitial Fibrosis in a Mouse Model of Diffuse Mesangial Sclerosis (ICGN Strain)"J.Vet.Med.Sci.. 63 (3). 299-307 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto,H.: "Microbiological Contamnation in Genetically Modified Animals and Proposals"Exp.Anim.. 50 (5). 397-407 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawashima, K.: "Protein restriction ameliorates renal tubulointerstitial nephritis and reduces renal transforming growth factor-beta expression in unilateral ureteral obstruction"Exp. Nephrol.. 10. 7-18 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okamoto, M.: "Linkage Mapping of the Mouse Nephrosis(nep) Gene to Chromosome 15"J.Vet.Med.Sci.. 63(12). 1347-1350 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawashima, K.: "Correlation between Renal Function and Tubulo-interstitial Lesions in Feline Progressive Kidney Disease"J. Jpn. Vet. Med. Assoc.. 54. 687-691 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kurosawa, T.: "A simple improvement of a Micro-Isolation-System(VIC)"Laboratory Animal and Environment. 10 (1). 53-54 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sawashima, K.: "Inhibition of Naturally Occurring Feline Chronic Renal Failure by Dietary-protein Restriction"J. Jpn. Vet. Med. Assoc.. 55. 591-595 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamada-Uchio, K.: "Abnormalities of extracellular matrix metabolisms in the kidney of ICGN mice, a strain of mice with hereditary nephrotic syndrome. In : Reproductive Biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Pub. Co.. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamaguchi, M.: "Renal anemia in ICR-derived glomerulonephritis (ICGN) mice. In : Reproductive Biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Pub. Co.. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamaguchi-Yamada, M: "Anemia associated with renal failure in the ICR-derived glomerulonephritis (ICGN) mice. In : Animal Frontier Science"Hokuto Pub. Co.. 364 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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