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2001 Fiscal Year Final Research Report Summary

Comparative epidemiogeographic pathlogical study of etiology of oral cancer between Japan and Russia, especially Siberian area

Research Project

Project/Area Number 12576023
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Morphological basic dentistry
Research InstitutionTOKYO MEDICAL AND DENTAL UNIVERSITY

Principal Investigator

TAKAGI Minoru  TOKYO MEDICAL AND DENTAL UNIVERSITY ・ GRADUATE SCHOOL, MOLECULAR PATHOLOGY, PROFESSOR, 大学院・医歯学総合研究科, 教授 (30014012)

Co-Investigator(Kenkyū-buntansha) SAKAMOTO Kei  TOKYO MEDICAL AND DENTAL UNIVERSITY ・ GRADUATE SCHOOL, RESEARCH, MOLECULAR PATHOLOGY, ASSOCIATE, 大学院・医歯学総合研究科, 助手 (00302886)
KATSUBE Ken-ichi  TOKYO MEDICAL AND DENTAL UNIVERSITY ・ GRADUATE SCHOOL, MOLECULAR PATHOLOGY, LECTURER, 大学院・医歯学総合研究科, 講師 (20233760)
Project Period (FY) 2000 – 2001
KeywordsOral cancer / Russia / HPV / LOH / multiple Occurrences / Field cancerization
Research Abstract

There are seen some differences in the clinicopathologic features among the different countries. And so epidemiogeographical Study of the oral cancer is important for understanding the exact behaviors and pathogenesis of this disease. In the present study we analyzed the human papillomavirus (HPV) and loss of heterozygosity (LOH) of the oral cancer from Japan, Russia and China. Among Japanese we compared the data between Tokyo and Okinawa where the climate is semitropical. We also analyzed the prevalence of HPV in the normal inhabitants of Miyako Island of the Okinawa Prefecture, in order to study of natural history of HPV. One of the characteristics in the pathogenesis of oral cancer is multiple occurrences, and this phenomenon might be explained by field cancerization. We studied the clonality of the oral multiple cancers, that is, whether multiple foci of the cancer are of monoclonal or polyclonal origin. The present study suggested the possibility of polyclonal origin.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Jiang W-W., Fujii H., Shirai T., Mega H., Takagi M.: "Accumulative increase of loss of heterozygosity from oral leukoplakia to foci of early cancerization in leukoplakia of the oral cavity"Cancer. 92. 2349-2356 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fernanda P.S., Katsube K., Takemura T., Takagi M.: "Perinuclear and cytoplasmic distribution of desmoglein in esophageal squamous cell carcinoma"Pathol. Res. Pract. 197. 85-91 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Terai M., Takagi M.: "Human papillomavirus in the oral cavity"Oral Medicine Pathology. 6. 1-12 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mega H., Jiang W-W., Takagi M.: "Immunohistochemical study of oral lichen planus associated with hepatitis C virus infection, oral lichenoid contact sensitivity reaction and idiopathic oral lichen planus"Oral Dis.. 7. 306-309 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kaneko T., Okiji T., Kan L., Suda H., Takagi M.: "An Immunoelectron microscopic study of class II major histocompatibility complex molecule-expressing macrophages and dendritic cells in experimental rat periapical lesions"Archiv. Oral Biol. 46. 713-720 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tang X., Jia L., Ouyang J., Takagi M.: "Comparative study of HPV prevalence in Japanese and Northeast Chinese oral carcinoma"J Oral Pathol Med.. (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Jiang W-W, Fujii H., Shirai T, Mega H., Takagi M.: "Accumulative increase of loss of heterozygosity from oral leukoplakia to foci of early cancerization in leukoplakia of the oral cavity"Cancer. 92. 2349-56 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fernanda P.S., Katsube K., Takemura T., Takagi M.: "Perinuclear and cytoplasmic distribution of desmoglein in esophageal squamous cell carcinoma"Pathol Res Pract. 197. 85-91 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Terai M and Takagi M: "Human papillomavirus in the oral cavity"Oral Medicine and Pathl. 6. 1-12

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mega H., Jiang W-W., Takagi M.: "Immunohistochemical study of oral lichen planus associated with hepatitis C virus infection, oral lichenoid contact sensitivity reaction and idiopathic oral lichen planus."Oral Dis. 7. 306-9 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kaneko T., Okiji T., Kan L., Suda H., Takagi M.: "Am immunoelectron microscopic study of class II major histocompatibility complex molecule-expressing macrophages and dendritic cells in experimental rat periapical lesions"Archiv Oral Biol,. 46. 713-20 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tan x., Jia l., Ouyang J., Takagi M.: "Comparative study of HPV prevalence in Japanese and Northeast Chinese oral carcinoma"J. Oral Pathol Med.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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