2001 Fiscal Year Final Research Report Summary

Does streptococcal ADP ribosyl cyclase/cADPR hydrolase evokeIgdassswitch?

Research Project

Project/Area Number	12670251
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Bacteriology (including Mycology)
Research Institution	Kanazawa University
Principal Investigator	KARASAWA Tadahiro Kanazawa University, Graduate School of Medical Science, Assosiate Professor, 大学院・医学研究科, 助教授 (90251917)
Project Period (FY)	2000 – 2001
Keywords	streptococcus pyogenes / cyclic ADP-ribose / NAD
Research Abstract	1. Distinct evidence of Ig class switch was not obtained when hybridoma cells were incubated with purified streptococcal ADP ribosyl cyclase/cADPR hydrolase. 2. The microbiologic status of streptococcal pharyngitis in pediatric outpatients was investigated. Children with clinical diagnosis of acute pharyngitis were enrolled. Of 360 specimens examined, 96 (26.7%) were beta hemplytic streptococci (BHS)-positive. The isolates were homogeneous for Lancefield's group and T antigen. Although group A was predominant (90 isolates, 93.8%), groups B (two isolates, 2.1%), C (one isolate, 1.0%), and G (three isolates, 3.1%) were also detected. It should be noticed that non-group A streptococci can not be detected with the currently used rapid antigen-detection tests. The results of T-serotyping suggest that human migration during summer vacation may provide an opportunity for streptococci to colonize in new hosts.

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