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2001 Fiscal Year Final Research Report Summary

MELANOCYTE MIGRATION AND REPIGMENTAION OF VITILIGO AND GREY HAIR-REGULATING MECHANISMS OF MELANOCYTE MIGRATION IN EPIDERMIAL-FOLLICULAR UNIT-

Research Project

Project/Area Number 12670821
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKOBE UNIVERSITY

Principal Investigator

HORIKAWA Tatsuya  KOBE UNIVERSITY, HOSPITAL, DEPARTMENT OF DERMATOLOGY, LECTURER, 医学部附属病院, 講師 (00173633)

Project Period (FY) 2000 – 2001
Keywordsmelanocyte / vitiligo / hair follicle / migration / Dok-1 / SHP-2 / IL-12 / melanoma
Research Abstract

We showed that SHP-2, a tyrosine phosphatase, plays an important role in cell locomotion, using dominant negative mutant.(Oncogene, 19:75-84,2000). We also found that Dok-1, a docking protein, plays an important role in the movement of B-16 melanoma cells (Mol Cell Biol, 21:5437-5446, 2001). We showed that IL-18 synergistically induces tumor rejection with IL-12 which is locally secreted by IL-12 transfected B-16 melanoma cells in vivo (Cancer Invest, 18;206-13, 2000). Using IL-12 transfected melanoma cells, we showed that CD4+T cell depletion induces both melanoma rejection and vitiligo-like depigmentation (J Invest Dermatol, 115:1059-1064,2000). In this regards, we found that IL-12 restores UV-induced suppression of resposiveness of Tlymphocytes (J Derm Sci, 24:190-202,2000). We also reported that giant melanosomes in Hermansky Pudlak syndrome which has a freature of impaired transportation of melanogenic enzymes in pigment cells (Br J Dermatol, 143:635-640,2000). Further, we showed that rab3A, an important G protein for intracellutar vgesicular transportation, is associated with melanosomes in pigment cells (Pigment Cell Res, 13:332-336,2000). Our findings will provide a useful information in establishing a new strategy of the treatment for depigmented disorders.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Inagaki K, et al.: "Roles for the protein tyrosine phosphatase SHP-2 in cytoskeltal organization cell adhesion, and cell migration revealed by overexpression of a dominant negative mutant"Oncogene. 19. 75-84 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagai H, et al.: "Antitumor effects on mouse melanoma elicited by local secretion of interleukin-12 and their enhancement by treatment with interleukin-18"Cancer Invest. 18. 206-213 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Horikawa T et al.: "Heterozygous HPS1 mutations in a case of Hermansky-Pudlak syndrome with giant melanosomes"Br J Dermatol. 143. 635-640 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Araki K, et al.: "Small GTPase Rab3A is associated with melanosomes in melanoma cells"Pigment Cell Res. 13. 332-336 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagai H et al.: "Elimination of CD4^+ T cells enhances antitumor effect of locally secreted interleukin-12 on B16 melanoma and induces vitiligo-like coat color alteration"J.Invest Dermatol. 115. 1059-1064 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hosoda t, et al.: "Inhibition of the motility and growth of B16F10 mouse melanoma cells by dominant negative mutant Dok-1"Mol Cell Biol. 21. 5437-5446 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀川 達也: "EBM皮膚科 真鍋求他編 尋常性白斑"文光堂. 275(259-265) (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inagaki K, Noguchi T, Matozaki T, Horikawa T, Fukunaga K, Tsuda M, Ichihashi M, Kasuga M: "Roles for the protein tyrosine phosphatase SHP-2 in cytoskeltal organization, cell adhesion, and cell migration revealed by overexpression of a dominant negative mutant"Oncogene. 19. 75-84 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagai H, Hara I, Horikawa T, Fujii M, Kurimoto M, Kamidono S, Ichihashi M: "Antitumor effects on mouse melanoma elicited by local secretion of interleukin-12 and their enhancement by treatment with interleukin-18"Cancer Invest. 18. 206-213 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Horikawa T, Araki K, Fukai K, Ueda M, Ueda T, Ito S, Ichihashi M: "Heterozygous HPS1 multations in a case of Hermansky-Pudlak syndrome with giant melanosomes"Br J Dematol. 143. 635-640 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Araki K, Horikkawa T, Oka M, Chakraborty AK, Nakagawa K, Itoh H, Funasaka Y, Ichihashi M: "Small GTPase Rab3A is associated with melanosomes in melanoma cells"Pigment Cell Res. 13. 332-336 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ando O, Suemoto Y, Kurimoto M, Horikawa T, Ichihashi M: "Deficient Th1-type immune responses via impaired CD28 signaling in ultraviolet B-injduced systemic immunosuppression and the restorative effect of IL-12"J Derm Sci. 24. 190-202 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagai H, Hara I, Horikawa T, Oka M, Kamidono S, Ichihashi M: "Elimination of CD4+T cells enhances antitumor effect of locally secreted interleukin-12 on B16 melanoma and induces vitiligo-like coat color alteration"J Invest Dermatol. 115. 1059-1064 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hosooka T, Noguchi T, Nagai H, Horikawa T, Matozaki T, Ichihashi M, Kasuga M: "Inhibition of the motility and growth of B16F10 mouse melanoma cells by dominant negative mutant of Dok-1"Mol Cell Biol. 21. 5437-5446 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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