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2001 Fiscal Year Final Research Report Summary

Identification and characterization of follicular stem cells

Research Project

Project/Area Number 12670825
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionSaga Medical School

Principal Investigator

NARISAWA Yutaka  Saga Medical School, Professor, 医学部, 教授 (60164498)

Co-Investigator(Kenkyū-buntansha) NAKAFUSA Jyunnji  Saga Medical School, Assistant, 医学部, 助手 (50253828)
MISAGO Noriyuki  Saga Medical School, Lecturer, 医学部, 講師 (90199977)
Project Period (FY) 2000 – 2001
KeywordsMerkel cell / Langerhans cell / hair follicle / three-dimension / 3次元 / 2次元
Research Abstract

The bulge area has not been paid attention except for the knowledge that the bulge area is the attachment site of the arrector pili muscles. However, it was suggested that follicular stem cells reside within the bulge area of human hair follicles, Therefore, we focused the characterization of epithelial cells composed of the bulge area. Immunohistochemical staining was carried out on the EDTA treated extracted human hair follicles, which enabled us to evaluate the true localization of each antibody labeled cells in three dimensions. NKI/beteb reactive melanocytes, CDla reactive Langerhans cells, cytokeratin!9 and/or cytokeratin15 reactive pleuripotential amplifying cells and cytokeratin20 reactive Merkel cells were clearly shown within the bulge. These findings of the extracted hair follicles were confirmed by the conventional vertical sections. Interestingly, double immunostaining techniques demonstrated that ir-Merkel cells contacted with ir-Langerhans cells within the bulge area. Theses findings may indicate some functional relationship between Merkel cells and Langerhans cells.

  • Research Products

    (1 results)

All Other

All Publications (1 results)

  • [Publications] Tatsurou Tanaka, Yutaka Narisawa: "Three-dimensional comparative study of Merkel cell distribution in various body sites of guinea pigs and rats"Arch Dermatol Res. 292. 173-179 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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