2002 Fiscal Year Final Research Report Summary
Apoptosis of Eccline Gland Epithelia in the skin from the ATL Patients and HTLV-I Healthy Carriers
| Project/Area Number |
12670830
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Dept. of Dermatology, Miyazaki Medical College (2001-2002)
Kagoshima University (2000) |
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Principal Investigator |
SETOYAMA Mitsuru Miyazaki Medical College, Dermatology, Professor, 医学部, 教授 (30128433)
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| Co-Investigator(Kenkyū-buntansha) |
KUROKAWA Motoki Miyazaki Medical College, Dermatology, Assist. Professor, 医学部, 講師 (90234591)
YOTSUMOTO Shin-ichi Kagoshima University, Dermatology, Assist. Professor, 医学部附属病院, 講師 (70244241)
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| Project Period (FY) |
2000 – 2002
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| Keywords | Apoptosis / ATLL / Eccrinegland / HTLV-I |
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| Research Abstract |
We have studied and confirmed that HTLV-1 infects not only lymphoid cells but also vascular endothelial cells and sweat gland epithelia. And, it is well known that virus-infected cells frequently exhibit apoptosis.
Thus, we investigated whether HTLV-1 infection caused apoptosis of the sweat gland epithelia in the specimen from ATLL patients and healthy HTLV-1 carriers.
As the results, apoptotic epithelial cells of the sweat glands were recognized from seropositive donors (14 of 31 cases of ATLL, 1 of 8 cases of carrier), but seronegative them. These apoptotic glands were always associated with CD8+ and TIA-1+ cell infiltration. These results also suggested that the event is relevant to sweating disturbance shown in ATLL patients.
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