Brain function and the sex difference in mental disorders using high-resolution non-invasive system

2001 Fiscal Year Final Research Report Summary

• Project/Area Number: 12670928
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: IWANAMI Akira Faculty of Medicine, The University of Tokyo, Associate Professor, 医学部・附属病院, 助教授 (80276518)
• Co-Investigator(Kenkyū-buntansha): YUMOTO Masato Faculty of Medicine, The University of Tokyo, Associate, 医学部・附属病院, 助手 (30240170) ; IRAMINA Keiji Faculty of Medicine, The University of Tokyo, Associate Professor, 医学部・大学院・医学系研究科, 助教授 (20211758) ; ITOH Kenji Post graduate School of Medicine, The University of Tokyo, Associate, 医学部・大学院・医学系研究科, 助手 (80010106)
• Project Period (FY): 2000 – 2001
• Keywords: ERP / MEG / MMN / NI / P300 / Schizophrerenia

Research Abstract

High-density event-related potential (ERP) recording system and high-density MEG recording system were used to examine the brain function and sex difference in mental disorders. Subjects were in patients with schizophrenia and autism. Mismatch negativity (MMN) in response to the change of vowels is significantly reduced in schizophrenia, which suggested the impairment of language processing. P300 amplitude was associated with the severity of though, disorder and was also associated with the global cognitive impairment.

Research Products

• [Publications] Ohno T, et al.: "Psychological covelates of social skills deficits in persons with schizophrenia"Psychiatry Research : Neuroimaging Section. 100. 155-167 (2000)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kasai K, et al.: "Brain lateralization for mismatch response to across-and with in-category charge of vowels"Neuroreport. 12. 2467-2471 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kasai K, et al.: "Neuropsychiatry and the auditory selective attention process"Current Opinion in Psychiatry. 14. 219-225 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Iwanami A, et al.: "Effects of risperidone on event-related potentials in schizophrenic patients"Pharmacophychiatry. 34. 73-79 (2001)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Watanabe A, et al.: "Verbal and procedural memory in schizophrenia with milder symptoms"Schizophrenia Research. 53. 263-265 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Ohno T, Ikebuchi E, Henomatsu K, Kasai K, Nakagome K, Iwanami A, Hiramatsu K, Hata A, Fukuda M, Honda M, Miyauchi M: "Psychological correlates of social skills deficits in persons with schizophrenia"Psychiatry Research : Neuroimaging Section. 100. 155-167 (2000)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kasai K, Yamada H, Kamio S, Nakagome K, Iwanami A, Fukuda M, Itoh K, Koshida I, Yumoto M, Iramina K, Kato N, Ueno S: "Brain lateralization for mismatch response to across- and within-category change of vowels"Neuroreport. 12. 2467-2471 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Kasai K, Nakagome K, Iwanami A, Fukuda M: "Neuropsychiatry and the auditory selective attention process"Current Opinion in Psychiatry. 14. 219-225 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Iwanami A, Okajima Y, Isono H, Shinoda J, Kasai K, Hata A, Fukuda M, Nakagome K, Kamijima K: "Effects of risperidone on event-related potentials in schizophrenic patients"Pharmacophychiatry. 34. 73-79 (2001)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Watanabe A, Kasai K, Nagakubo S, Kamio S, Murakami T, Hata A, Iwanami A, Nakagome K, Fukuda M, Kato N: "Verbal and procedural memory in schizophrenia with milder symptoms : implications for psychosocial intervention"Schizophrenia Research. 53. 263-265 (2002)
  • Description: 「研究成果報告書概要(欧文)」より