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2002 Fiscal Year Final Research Report Summary

Analysis of p14/ARF in adult T cell leukemia (ATL)

Research Project

Project/Area Number 12671010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionNihon University

Principal Investigator

HATTA Yoshihiro  Nihon Univ. School of Med., 医学部, 助手 (30318430)

Co-Investigator(Kenkyū-buntansha) ARIMA Naomichi  Kagoshima Univ. School of Med., 医学部, 講師 (30175997)
Project Period (FY) 2000 – 2002
KeywordsATL / p14 / ARF / tumor suppressor gene
Research Abstract

The role of p14/ARF in the development of adult T cell leukemia/lymphoma (ATLL) was studied. p14/ARF DNA was deleted in a cell line, OKM3T, among nine ATLL related cell lines (MT1, MT2, HUT102, OKM3T, F6T, K3T, Oh13T, S1T, and SU9T01). The gene was not expressed in OKM3T and weakly expressed in S1T by RT-PCR analysis. We are investigating the methylation status in the promoter region of p14/ARF in S1T. p14/ARF and MDM2 proteins were detected in one and two of 11 lymphnodes derived from primary ATLL patients by immunohistochemical staining, respectively. P53 protein positive cells were 7.51% (mean) in ATLL cells, which is not significantly different compared with other lymphoma cells. Protein expression of both MDM2 and p53 were correlated neither with the expression of p14/ARF nor grade of malignancy in lymphoma. The regulation mechanisms of p14/ARF, MDM2, and p53 as well as contribution of these genes to development of ATLL should be further studied.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Komatsu N. et al.: "Mutations of the E2F4 gene in hematological malignancies having microsatellite instability"Blood. 95. 1509-1510 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hatta Y, et al.: "Analysis of 20-year follow-up study of LVP regimen for adult acute lymphoblastic leukemia"Int J Hemat. 74. 157-164 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] Matsukawa Y, et al.: "Seroprevalence of Helicobacter pylori after bone marrow transplantation"Int J Immunotherapy. 17. 21-24 (2001)

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      「研究成果報告書概要(和文)」より
  • [Publications] Hatta Y, et al.: "Role of tumor suppression genes in the development of ATLL"Leukemia. 16. 1069-1085 (2002)

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      「研究成果報告書概要(和文)」より
  • [Publications] Hatta Y, et al.: "Purging in autologous hematopoietic stem cell transplantation using ATP and 4HC"Leuk Res.. 26. 477-482 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hatta Y, et al.: "Mutational analysis of IKBα in hematologic malignancies"Int J.Mol.Med. 11. 239-242 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Komatsu N, Takeuchi S, Ikezoe T, Tasaka T, Hatta Y, Machida H, Williamson IK, Bartram CR, Koeffler HP, Taguchi H: "Mutations of the E2F4 gene in hematological malignancies having microsatellite instability"Blood. 95(4). 1509-1510 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hatta Y, Takeuchi J, Ohshima T, Horikoshi A, Iizuka Y, Kawamura M, Kanemaru M, Horie T: "Analysis of 20-year follow-up study of LVP regimen for adult acute lymphoblastic leukemia"International Journal of Hematology. 74(2). 157-164 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsukawa Y, Aizawa S, Itoh T, Hatta Y, Nishinarita S, Horie T, Suzuki A, Takahashi S, Asano S, Mine T: "Seroprevalence of Helicobacter Pylori after bone marrow transplantation"International Journal of Immunotherapy. 17(1). 21-24 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hatta Y, Koeffler HP: "Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL)"Leukemia. 16(6). 1069-1085 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hatta Y, Itoh T, Baba M, Miyajima T, Shimojima H, Sawada U, Horie T: "Purging in autologous hematopoietic stem cell transplantation using adenosine triphosphate (ATP) and 4-hydroperoxycyclophosphamide (4HC)"Leukemia Research. 26(5). 477-482 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miwa M, Fukunishi I, Murakami M, Kura Y, Hatta Y, Yamazaki T, Ito T, Takeuchi J, Sawada U.: "Psychiatric symptoms with non-Hodgkin's lymphoma"Psychosomatics. 43(6). 507-508 (2002)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Nagaizumi K, Inaba H, Suzuki T, Hatta Y, Hagiwara T, Amano K, Arai M, Fukutake K: "Two double heterozygous mutation in the F7 gene show different manifestations"British Journal of Haematology. 119(4). 1052-1058 (2002)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Saitoh T, Nakamura T, Inoue M, Hatta Y, Yamazaki T, Takeuchi J, Sawada U, Horie T: "Different clones of t(1;12)/t(12;12) involving the ETV6 gene in a case of myeloid leukemia"Cancer Genetics and Cytogenetics. 137(2). 138-141 (2002)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Hatta Y, Arima N, Machino T, Itoh T, Hashimoto S, Takeuchi J, Sawada U, Hayakawa S, Yamamoto T, Horie T: "Mutational analysis of IkBα in hematologic malignancies"International Journal of Molecular Medicine. 11(2). 239-242 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aikawa S, Hatta Y, Tanaka M, Kaneita Y, Yasukawa K, Sawada U, Horie T, Tsuboi I, Aizawa S: "Requirement of soluble factors produced by bone marrow stromal cells on the growth of novel established human myeloma cell line"International Journal of Oncology. 22(3). 631-637 (2003)

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      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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