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2001 Fiscal Year Final Research Report Summary

Chronological gene expression profile in acute renal failure using CDNA array method

Research Project

Project/Area Number 12671026
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

NOIRI Eisei  The Univ. of Tokyo, Dept. of Nephrology & Endocrinology, Assist. Professor, 医学部・附属病院, 助手 (00301820)

Co-Investigator(Kenkyū-buntansha) TOKUNAGA Katsushi  The Univ. of Tokyo, Dept. Human Genetics, Professor & Chairman, 大学院・医学系研究科, 教授 (40163977)
NAKAO Akihide  The Univ. of Tokyo, Dept. Hemodiafiltration, Lecturer, 医学部・附属病院, 講師 (10159056)
Project Period (FY) 2000 – 2001
KeywordsIschemia-reperfusion / Acute renal failure / Human proximal tubular epithelial cells / Hypoxic stress / Macro-array method / non RI
Research Abstract

1.Non-RI CDNA array method was established utilizing low cycle RT-PCR.
2.In vitro hypoxia reoxyganetion model was established using human proximal epithelial cells. Time points that distinguish reversible from irreversible damage was determined.
3.Mice renal ischemia-reperfusion model was established as in vivo model.
4.Gene profiles in reversible/irreversible damage from hypoxia reoxyganetion were obtained using non-RI CDNA array.
5.Subgroup of genes that increase expression during reversible phase and decrease in irreversible damage are focused-as the marker genes prophetic of reversibility in in vitro model.
6.Subgroup of genes that increase expression during reversible phase and decrease in irreversible damage are focused as the marker genes prophetic of reversibility in in vivo model.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Goligorsky MS, Brodsky SV, Noiri E: "Nitric oxide in acute renal failure : NOS versus NOS"Kidney Int. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto T, Tada T, Brodsky Sv, Tanaka H, Noiri E, Kajiya F, Goligorsky MS: "Intravital videomicroscopy of peritubular capillaries in renal ischemia"Am J Physiol. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noiri E, Nakao A, Uchida K, Tshukahara H, Ohno M, Fujita T, Brodsky S, Goligorsky MS: "Oxidative and nitrosative stress in acute renal ischemia"Am J Physiol. 281. F948-F957 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noiri E, Ozawa H, Fujita T, Nakao A: "Pharmacokinetics of cetirizine in chronic hemodialysis patients"Nephron. 89. 101-104 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki T, Takemura H, Noiri E, Nosaka K, Toda A, Taniguchi S, Uchida K, Fujita T, Kumura S, Nakao A: "Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells"Free Radic Biol Med. 31. 615-623 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Usui T, Hara M, Satoh H, Moriyama N, Kagaya H, Amano S, Oshika T, Ishii Y, Ibaraki N, Hara C, Kunimi M, Noiri E, Tsukamoto K, Inatomi J, Kawakami H, Endou H, Igarashi T, Goto A, Fujita T, Araie M, Seki G: "Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis"J Clin Invest. 108. 107-115 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto T, Tada T, Brodsky SV, Tanaka H, Noiri E, Kajiya F, Goligorsky MS: "Intrayital Videomicroscopy of peritubular capillaries in renal ischemia"Am J Physiol Renal Physiol. epub ahead of print. (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noiri E, Nakao A, Uchida K, Tsukahara H, Ohno M, Fujita T, Brodsky S, Goligorsky M: "Scavenging of peroxynitrite ameliorates lipid peroxidation and DNA damage in experimental ischemic acute renal failure"Am J Physiol Renal Physiol. 281. F948-F957 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noiri E, Ozawa H, Fujita T, Nakao A: "Pharmacokinetics of cetirizine in chronic hemodialysis patients : multiple-dose study"Nephron. 89. 101-4 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki T, Takemura H, Noiri E, Nosaka K, Toda A, Taniguchi S, Uchida K, Fujita T, Kimura S, Nakao A: "Puromycin aminonucleoside induces apoptosis and increases HNE in cultured glomerular epithelial cells"Free Radio Biol Med. 31. 615-23 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Usui T, Hara M, Satoh H, Moriyama N, Kagaya H, Amano S, Oshika T, Ishii Y, Ibaraki N, Hara C, Kunimi M, Noiri E, Tsukamoto K, Inatomi J, Kawakami H, Endou H, Igarashi T, Goto A, Fujita T, Araie M, Seki G.: "Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis"J Clin Invest. 108. 107-15 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Goligorsky MS, Brodsky SV, Noiri E: "Nitric oxide in acute renal failure : NOS versus NOS."Kidney Int (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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