2002 Fiscal Year Final Research Report Summary
Relationship between sleep and anesthesia
| Project/Area Number |
12671449
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Hirosaki University |
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Principal Investigator |
TAKAHASHI Satoshi Hirosaki University, University Hospital, Senior Instructor, 医学部附属病院, 助手 (10236276)
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| Co-Investigator(Kenkyū-buntansha) |
KUSHIKATA Tetsuya Hirosaki University, University Hospital, Instructor, 医学部附属病院, 医員 (80250603)
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| Project Period (FY) |
2000 – 2002
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| Keywords | Sleep / Anesthesia / Sleep Deprivation / Ketamine / Propofol / EEG / Cytokine |
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| Research Abstract |
It is hypothesized that stimuli to enhance sleep may make the potency of anesthetics strong. To test the hypothesis, we studied the effect of sleep deprivation on the anesthetic potency. In the first study, rats were performed 4-h, 6-h, 8-h sleep deprivation. After the sleep deprivation, the animals were injected ketamine or propofol intraperitoneally. Then, the rats were measured the anesthetic time that was defined as the time between the loss of righting reflex. The anesthetic time after ketamine or propofol injection was significantly increased by 6-h and 8-h sleep deprivation. In the second study, the anesthetic potency of ketamine after 8-h sleep deprivation was determined by measuring electroencephalogram and electromyogram in rats. The result was the same as the first study. 8-h sleep deprivation significantly prolonged the anesthetic time and enhanced electroencephalogram slow wave activity during anesthesia. These results support the hypothesis that stimuli to enhance sleep may make the potency of anesthetics strong.
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