2002 Fiscal Year Final Research Report Summary
Cartilage differentiation in testicular cancer
| Project/Area Number |
12671553
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Saitama Medical School |
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Principal Investigator |
UENO Munehisa Saitama Medical School, Faculty of Medicine, Associate Professor, 医学部, 助教授 (60167286)
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| Co-Investigator(Kenkyū-buntansha) |
NONAKA Shoichi Saitama Medical School, Faculty of Medicine, Fellow, 医学部, 助手 (70255537)
TSUKAMOTO Takuji Saitama Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 (90322411)
DEGUCHI Nobuhiro Saitama Medical School, Faculty of Medicine, Professor, 医学部, 教授 (90118977)
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| Project Period (FY) |
2000 – 2002
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| Keywords | testicular cancer / cartilage_differentiation / retinoic acid |
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| Research Abstract |
We have investigated the effects of retinoic acids on the production of parathyroid hormone related protein (PTHrP) and on the cell cycle of our cultured testicular carcinoma cell line, KU-MT. In vitro the cells were shown to produce PTHrP, but the production was not enhanced in response to TAC-101, an RAR-α agonist, which was provided by Taiho Pharmaceutical Inc. This compound arrested the cell cycle in G1 and reduced the percentage of S phase. The arrested cells consequently became apoptotic in part. However, the mechanism of the cytotoxic effects was not clarified.
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