2001 Fiscal Year Final Research Report Summary
β-catenin abnormalities in pediatric malignant solid tumors
| Project/Area Number |
12671738
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Osaka University |
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Principal Investigator |
KUSAFUKA Takeshi Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (70263267)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Akira Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (40028569)
WASA Masafumi Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (10240467)
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| Project Period (FY) |
2000 – 2001
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| Keywords | β-catenin / childhood / hepatoblastoma / nephroblastoma / rhabdomyosarcoma / neuroblastoma |
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| Research Abstract |
(1) To investigate implication of p-catenin in tumorigenesis of childhood maligmant solid tumors, gene alterations and protein expression patterns of β-catenin were analyzed.
(2) Beta-catenin gene alterations were detected in 77% of hepatoblastomas and 25% of nephroblastomas investigated, and all alterations were considered to have a serious effect on phosphorylation by GSK-3β.
(3) Apparent distinction was observed between hepatoblastoma and hephroblastoma in β-catenin alteration -patterns.
(4) Abnormal protein expression pattern, such as intense immunostaining in tumor cell nuclei, was uniformly observed in a subsets of tumors of different histological types.
(5) Such abnormal accumulation of β-catenin was detected in all hepatoblastomas, 40% of nephroblastomas and several rhabdomyosarcomas, suggesting a common involvement of β-catenin abnormalities in tumorigenesis of these tumors.
(6) In neuroblastoms, any β-catenin abnormalities were detected.
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