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2002 Fiscal Year Final Research Report Summary

Electron microscopic study on oral lesions of HIV-infection

Research Project

Project/Area Number 12671952
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKagoshima University

Principal Investigator

SUGIHARA Kazumasa  Kagoshima University Dental School, Professor, 歯学部, 教授 (00117516)

Co-Investigator(Kenkyū-buntansha) KAMIKAWA Yasuko  Kagoshima University Dental School, Research assistant, 歯学部, 教務職員 (70253903)
ISHIGAMI Tetsuro  Kagoshima University Dental Hospital, Associate Professor, 歯学部附属病院, 助教授 (30232276)
Project Period (FY) 2000 – 2002
KeywordsHIV / Oral lesion / Oral Candidasis / HAART / Scanning electron microscopy / Transmission electron microscopy
Research Abstract

We investigated on oral lesions of 50 HIV-seropositive patients treated with highly active antiretroviral therapy for over 6 months at the Department of Infectious Disease in Charite Hospital, Humboldt University in Berlin. The patients consisted of 42 men and 8 women with a mean age of 41.5 years (24-61 years). 29 patients were homosexuals, 6 patients were heterosexuals, 7 patients were drug abusers, and 8 patients were others. Distribution of CDC-classification was 1 in A1, 8 in A2, 1 in A3, 1 in B1, 6 in B2, 13 in B3 and 20 in C3. Oral candidiasis was observed in 27 patients, oral candidiasis with other oral lesions was observed in 11 patients, and oral hairy leukoplakia was observed in 2 patients. Candida species were isolated in 38 patients. Isolated Candida species were Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis. Scanning electron microscopic observation revealed a lot of slender thread-like hyphae of Candida albicans on the surface of the exfoliative cells and in the intercellular spaces. Numerous spherical yeast-like mycelium which were adherent to the surface of the epithelial cells were observed. Hyphe of Candida albicans were found in the cytoplasm of the epithelial cells in the stratum corneum with transmission electron microscopy.

  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 杉原一正: "AIDS(エイズ)"日本歯科医師会雑誌. 55・11. 78-79 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 白川正順, 伊東隆利, 河村 博 編: "有病者歯科診療(分担執筆)、杉原一正:エイズ(AIDS)"医歯薬出版株式会社. 304(147-149) (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazumasa Sugihara: "AIDS"The Journal of The Japan Dental Association. Vol. 55-No. 11. 78-79 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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