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2001 Fiscal Year Final Research Report Summary

Development of frontier life science research for prevention and therapy of endemic diseases in Asia and the Pacific Rim Region

Research Project

Project/Area Number 12800004
Research Category

Grant-in-Aid for Special Purposes

Allocation TypeSingle-year Grants
Research InstitutionJapanese Foundation for Cancer Research

Principal Investigator

KOIKE Katsuro  Japanese Foundation for Cancer Research, Cancer Institute, Department Chief, 癌研究所・遺伝子研究施設部, 部長 (30085625)

Co-Investigator(Kenkyū-buntansha) ASASHIMA Makoto  Graduate School of Arts and Sciences, The University of Tokyo, Professor, 大学院・総合文化研究科, 教授 (00090564)
MIYAJIMA Atsushi  Institute of Molecular and Cellular Biosciences, The University of Tokyo, Professor, 分子細胞生物学研究所, 教授 (50135232)
ARAI Ken-ichi  Institute of Medical Science, The University of Tokyo, Professor, 医科学研究所, 教授 (00012782)
SUGINO Akio  Research Institute for Microbial Deseases, Osaka University, Professor, 微生物病研究所, 教授 (90231737)
ITO Yoshiaki  Institute for Virus Research, Kyoto University, Professor, ウイルス研究所, 教授 (80004612)
Project Period (FY) 2000 – 2001
KeywordsFrontier Life Sciences / Asia and Pacific Rim region / Asia-Pacific Molecular Biology Network / Genomics / Proteomics / International collabolation
Research Abstract

This project performs support surveillance study and joint research on subjects of priority needs, in order to advance R&D in the field of frontier life science, targeting to prevent development and to conduct medical treatment of endemic diseases in Asia and the Pacific Rim region. For this realization, frequent information exchange and collaboration are encouraged among researchers of the Asia-Pacific International Molecular Biology Network (A-IMBN), by which, in turn, Japanese scientists will contribute in Asia and the Pacific Rim region. Mutual exchange of researchers and research collaboration are intended to facilitate investigation of the project priorities and to build the cooperative research system with the foreign researchers.
Based on the results from wide surveillance study on the essential research projects, in the Heisei 12 fiscal year, study was also conducted in the Heisei 13 fiscal year, focusing on the priority research projects. The following projects were selected.
1 … More . Genomics in infectious diseases and immunology. 2. Genomics and proteomics of cancer. 3. Human genome polymorphism. 4. Biotechnology of pharmacogenomics and cell therapy.
Under this 2-years project, the following international activities were supported for information and researcher exchanges and the research collaboration.
1. In September, 2000, the A-IMBN conference was held in Brisbane, Australia.
2. In March, 2001, the international symposium of life science was held in Tokyo.
3. In July, 2001, the A-IMBN symposium was supported in the International Congress of Developmental Biology, in Kyoto.
4. In November, 2001, the A-IMBN conference was held in Taipei.
5. The Singapore/Japan symposium was held in March, 2002 in Singapore.
6. Infrastructure of the international information network was advanced.
7. In March, 2001, the mutual exchange of the researcher between Singapore and Japan was discussed. A member of this project will move to the Institute of Molecular and Cell Biology of Singapore, in April, 2002. Less

  • Research Products

    (86 results)

All Other

All Publications (86 results)

  • [Publications] Chong Feng Gao: "Caspase-dependent cytosolic release of cytochrome c and membrane translocation of Bax in p53-induced apoptosis"Exp. Cell Res.. 264. 145-151 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masai H: "Cdc7 kinase complex : a key regulator in the initiation of DNA replication"J Cell Physiol. 190. 287-296 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeda M: "Cell cycle-dependent interaction of Mad2 with conserved Box1/2 region of human granulocyte-macrophage colony-stimulating factor receptor common betac"J Biol Chem.. 276. 41803-41809 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchiyama M: "Sna41goa1, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with polalpha"Mol Genet Genomics. 265. 1039-1049 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Liu J: "Inhibition of NFATx activation by an oligopeptide : disrupting the interaction of NFATx with calcineurin"J Immunol. 167. 2677-2687 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takenaka Y: "Transformation of Paramecium caudatum with a novel expression vector harboring codon-optimized GFP gene"Gene. 284. 233-240 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanaka Y: "Anti-CD44 Monoclonal Antibody (IM7) Induces Murine Systemic Shock Mediated by Platelet Activating Factor"J Autoimmun. 18. 9-15 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuura T: "Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes"J Inorg Biochem. 88. 183-191 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takano S: "Identification and characterization of molecular interactions between glucose-regulated proteins (GRPs) mortalin/GRP75/peptide-binding protein 74 (PBP74) and GRP94"Biochem J. 357. 393-398 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takano S: "p53-independent upregulation of p21 WAF1 in NIH 3T3 cells malignantly transformed by mot-2"Cell Res. 11. 55-60 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsui T: "K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development"EMBO J. 21. 1021-1030 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeuchi M: "Cultivation of aorta-gonad-mesonephros-derived hematopoietic stem cells in the fetal liver microenvironment amplifies long-term repopulating activity and enhances engraftment to the bone marrow"Blood. 99. 1190-1196 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murakami R: "Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. I. Production, isolation and biological activity"J Antibiot. 54. 710-713 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kinoshita T: "Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment"Exp Hematol. 29. 1091-1097 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagayama H: "Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim"Bone Marrow Transplant. 29. 197-204 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tomonari A: "Severe autoimmune thrombocytopenia after allogeneic bone marrow transplantation for aplastic anemia"Int J Hematol. 74. 228-232 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ooi J: "Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related secondary acute myeloid leukaemia"Br J Haematol. 114. 834-836 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okada M: "Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc"EMBO J. 21. 675-684 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinagawa T: "Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice"Oncogene. 20. 8100-8108 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takagi T: "Murine Schnurri-2 is required for positive selection of thymocytes"Nat Immunol. 2. 1048-1053 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Harbers M: "Intracellular localization of the Ret finger protein depends on a functional nuclear export signal and protein kinase C activation"J Biol Chem. 276. 48596-48607 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Khan MM: "PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb"J Biol Chem. 276. 43491-43494 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanikawa J: "Regulation of c-Myb activity by tumor suppressor p53"Blood Cells Mol Dis. 27. 479-482 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kokura K: "The Ski protein family is required for MeCP2-mediated transcriptional repression"J Biol Chem. 276. 34115-34121 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wada M: "The Second Largest Subunit of Mouse DNA Polymerase epsilon, DPE2, Interacts with SAP18 and Recruits the Sin3 Co-Repressor Protein to DNA"J Biochem (Tokyo). 131. 307-311 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kakeda M: "Role of the thrombopoietin (TPO)/Mpl system : c-Mpl-like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis"Dev Growth Differ. 44. 63-75 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayata T: "Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies"Mech Dev. 112. 37-51 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onuma Y: "Stroma-dependent maintenance of cytokine responsive hematopoietic progenitor cells derived from long-term bone marrow culture"Proc Natl Acad Sci USA. 99. 2020-2025 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Onuma Y: "Multiple nodal-related genes act coordinately in Xenopus embryogenesis"Dev Biol. 241. 94-105 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Igarashi T: "Cloning and characterization of the Xenopus laevis p8 gene"Dev Growth Differ. 43. 693-698 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishinakamura R: "Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development"Development. 128. 3105-3115 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ariizumi T: "In vitro induction systems for analyses of amphibian organogenesis and body patterning"Int J Dev Biol. 45. 273-279 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichigi J: "Dome formation and tubule morphogenesis by Xenopus kidney A6 cell cultures exposed to microgravity simulated with a 3D-clinostat and to hypergravity"In Vitro Cell Dev Biol Anim. 37. 31-44 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawasaki Y: "Yeast replicative DNA polymerases and their role at the replication fork"Mol Cells. 12. 277-285 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Waga S: "DNA polymerase varepsilon is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts"Proc Natl Acad Sci USA. 98. 4978-4983 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Osato M: "Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias"Int J Hematol. 74. 245-251 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishimoto O: "Possible oncogenic potential of DeltaNp73 : a newly identified isoform of human p73"Cancer Res. 62. 636-641 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tetsuka K: "Acidic amino acid transport characteristics of a newly developed conditionally immortalized rat type 2 astrocyte cell line (TR-AST)"Cell Struct Funct. 26. 197-203 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayashi K: "Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage"J Immunol. 167. 4957-4965 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Obinata M: "Possible applications of conditionally immortalized tissue cell lines with differentiation functions"Biochem Biophys Res Commun. 286. 667-672 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato AK: "Stromal cells provide signals different from cytokines for STAT5 activation in hematopoietic cells"Cell Struct Funct. 26. 95-101 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kitaoka E: "Establishment and characterization of chondrocyte cell lines from the costal cartilage of SV40 large T antigen transgenic mice"J Cell Biochem. 81. 571-582 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchiyama M: "Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast"J Biol Chem. 276. 26189-26196 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chong Feng Gao: "Caspase-dependent cytosolic release of cytochrome c and membrane translocation of Bax in p53-mduced apoptosis"Exp. Cell Res.. 264. 145-151 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masai H: "Cdc7 kinase complex : a key regulator in the initiation of DNA replication"J Cell Physiol.. 190. 287-296 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeda M: "Cell cycle-dependent interaction of Mad2 with conserved Box1/2 region of human granulocyte-macrophage colony-stimulating factor receptor common betac"J Biol Chem.. 276. 41803-41841 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchiyama M: "Sna41goal, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with polalpha"Mol Genet Genomics. 265. 1039-1049 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Liu J: "Inhibition of NFATx activation by an oligopeptide : disrupting the interaction of NFATx with calcineurin"J Immunol.. 167. 2677-2687 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takenaka Y: "Transformation of Paramecium caudatum with a novel expression vector harboring codon-optimized GFP gene"Gene. 284. 233-240 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka Y: "Anti-CD44 Monoclonal Antibody (IM7) Induces Murine Systemic Shock Mediated by Platelet Activating Factor"J Autoimmun. 18. 9-15 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura T: "Germ cell-specific nucleocytoplasmic shuttling protein, tesmin, responsive to heavy metal stress in mouse testes"J lnorg Biochem. 88. 183-191 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takano S: "Identification and characterization of molecular interactions between glucose-regulated protein (GRPs) mortalin/GRP75 /peptide-binding protein 74 (PBP74) and GRP94"Biochem J.. 357. 393-398 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takano S: "p53-independent upregulation of p21 WAF1in NIH 3T3 cells malignantly transformed by mot-2"Cell Res.. 11. 55-60 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsui T: "K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development"EMBO J. 21. 1021-1030 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeuchi M: "Cultivation of aorta-gonad-mesonephros- derived hematopoietic stem cells in the fetal liver microenvironment amplifies long-term repopulating activity and enhances engraftment to the bone marrow"Blood. 99. 1190-1196 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murakami R: "Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp.1. Production, isolation and biological activity"J Antibiot.. 54. 710-713 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kinoshita T: "Oncostatin M suppresses generation of lymphoid progenitors in fetal liver by inhibiting the hepatic microenvironment"Exp Hematol.. 29. 1091-1097 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onuma Y: "Multiple nodal-related genes act coordinately in Xenopus embryogenesis"Dev Biol.. 241. 94-105 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Igarashi T: "Cloning and characterization of the Xenopus laevis p8 gene"Dev Growth Differ. 43. 693-698 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishinakamura R: "Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development"Development. 128. 3105-3115 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ariizumi T: "In vitro induction systems for analyses of amphibian organogenesis and body patterning"Int J Dev Biol.. 45. 273-279 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ichigi J: "Dome formation and tubule morphogenesis by Xenopus kidney A6 cell cultures exposed to microgravity simulated with a 3D-clinostat and to hypergravity"In Vitro Cell Dev Biol Anim.. 37. 31-44 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawasaki Y: "Yeast replicative DNA polymerases and their role at the replication fork"Mol Cells. 12. 277-285 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Waga S: "DNA polymerase varepsilon is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts"Proc Natl Acad Sci USA. 98. 4978-4983 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Osato M: "Point mutations of the RUNx1/AML1 gene in sporadic and familial myeloid leukemias"Int J Hematol.. 74. 245-251 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishimoto O: "Possible oncogenic potential of DeltaNo73 : a newly identified isoform of human p73"Cancer Res.. 62. 636-641 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tetsuka K: "Acidic amino acid transport characteristics of a newly developed conditionally immortalized rat type 2 astrocyte cell line (TR-AST)"Cell Struct Funct. 26. 197-203 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayashi K: "Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage"J Immunol.. 167. 4957-4965 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Obinata M: "Possible applications of conditionally immortalized tissue cell lines with differentiation functions"Biochem Biophys Res Commun.. 286. 667-672 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato AK: "Stromal cells provide signals different from cytokines for STAT5 activation in hematopoietic cells"Cell Struct Funct.. 26. 95-101 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitaoka E: "Establishment and characterization of chondrocyte cell lines from the costal cartilage of SV40 large T antigen transgenic mice"J Cell Biochem.. 81. 571-582 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagayama H: "Transient hematopoietic stem cell rescue using umbilical cord blood for a lethally irradiated nuclear accident victim"Bone Marrow Transplant. 29. 197-204 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tomonari A: "Severe autoimmune thrombocytopenia after allogeneic bone marrow transplantation for aplastic anemia"Int J Hematol.. 74. 228-232 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ooi J: "Unrelated cord blood transplantation for adult patients with myelodysplastic syndrome-related secondary acute myeloid leukaemia"Br J Haematol.. 114. 834-836 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okada M: "Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc"EMBO J. 21. 675-684 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinagawa T: "Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice"Oncogene. 2. 8100-8108 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takagi T: "Murine Schnurri-2 is required for positive selection of thymocytes."Nat Immunol.. 2. 1048-1053 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harbers M: "Intracellular localization of the Ret finger protein depends on a functional nuclear export signal and protein kinase C activation"J Biol Chem.. 276. 48596-48648 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Khan MM: "PML-RARalpha alleviates the transcriptional repression mediated by tumor suppressor Rb"J Biol Chem.. 276. 43491-43543 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanikawa J: "Regulation of c-Myb activity by tumor suppressor p53"Blood Cells Mol Dis.. 27. 479-482 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kokura K: "The Ski protein family is required for MeCP2-mediated transcriptional repression"J Biol Chem.. 276. 34115-34234 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wada M: "The Second Largest Subunit of Mouse DNA Polymerase epsilon, DPE2, Interacts with SAP18 and Recruits the Sin3 Co-Repressor Protein to DNA"J Biochem. (Tokyo). 131. 307-311 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kakeda M: "Role of the thrombopoietin (TPO)/Mpl system : c-Mpl-like molecule/TPO signaling enhances early hematopoiesis in Xenopus laevis"Dev Growth Differ.. 44. 63-75 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayata T: "Conservation of Pax 6 function and upstream activation by Notch signaling in eye development of frogs and flies"Mech Dev.. 112. 37-51 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Onuma Y: "Stroma-dependent maintenance of cytokine responsive hematopoietic progenitor cells derived from long-term bone marrow culture"Proc Natl Acad Sci USA. 99. 2020-2025 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchiyama M: "Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast"J Biol Chem.. 276. 26189-26226 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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