2004 Fiscal Year Final Research Report Summary
International comparison of subclinical atherosclerosis among the Japanese and American men aged 40-49
| Project/Area Number |
13307016
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
UESHIMA Hirotsugu Shiga University of Medical Science, Department of Medicine, Professor, 医学部, 教授 (70144483)
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| Co-Investigator(Kenkyū-buntansha) |
MURATA Kyoshi Shiga University of Medical Science, Department of Medicine, Professor, 医学部, 教授 (20127038)
KASHIWAGI Atsunori Shiga University of Medical Science, Department of Medicine, Professor, 医学部, 教授 (20127210)
NAKAMURA Yasuyuki Kyoto Women's University, Department of Home Economics, 家政学部, 教授 (20144371)
OKAMURA Tomonori Kyoto Women's University, Department of Home Economics, 医学部, 助教授 (00324567)
KADOWAKI Takashi Kyoto Women's University, Department of Home Economics, 医学部, 助手 (30324578)
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| Project Period (FY) |
2001 – 2004
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| Keywords | international collaborative study / the United States / Atherosclerosis / coronary calcification / physical activity |
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| Research Abstract |
We conducted an international collaborative study, ERA JUMP (EBT and Risk Factor Assessment among Japanese and U.S. Men in the Post World-War II Birth Cohort), cooperating with the University of Pittsburgh and Pacific Health Research Institute in Hawaii. The purpose of this study was to elucidate and compare the progression of subclinical atherosclerosis among the Japanese and American men aged 40-49, and explore risk factors for atherosclerosis.
We found the following results during the study period ; 1)the progression of subclinical atherosclerosis was severer in the Americans than in the Japanese, regardless of the unfavorable risk profile in the Japanese such as higher blood pressure, higher smoking prevalence, and similar levels of cholesterol, 2)the Japanese American men in Hawaii had severer levels of subclinical atherosclerosis than the Japanese men in Japan, indicating that the determinant of subclinical atherosclerosis is not genetic difference, and 3)physical activity did not seem to affect the progression of atherosclerosis, although we lacked in sufficient sample size and information in our pilot study on physical activity.
For the purpose of standardization of blood sample examinations, samples were shipped to a laboratory in the University of Pittsburgh. We plan to examine lipoprotein profiles by NMR, emerging risk factors such as adipocytokines and possible genetic differences.
Future directions of the study would be : 1)to elucidate the relationship between atherosclerosis and insulin resistance, 2)to add a new samples from South Korea whose risk profile is more favorable, but the progression of subclinical atherosclerosis is severer than the Japanese, and 3)to expand the age group in the Japanese
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