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2003 Fiscal Year Final Research Report Summary

Deployment and establishment adult living donor liver transplantation-Development of the immunosuppression treatment based on gene analysis treatment based on a gene analysis

Research Project

Project/Area Number 13307038
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

TANAKA Koichi  Kyoto university, faculty of medicine, Professor, 医学研究科, 教授 (20115877)

Co-Investigator(Kenkyū-buntansha) EGAWA Hiroto  Kyoto university, faculty of medicine, Associate professor, 医学研究科, 助教授 (40293865)
KIUCHI Tetsuya  Nagoya University, School of medicine, Professor, 医学研究科, 教授 (40303820)
UEMOTO Shinji  Mie university, Faculty of medicine, Professor, 医学部, 教授 (40252449)
KASAHARA Mureo  Kyoto university, faculty of medicine, Instructor, 医学研究科, 助手 (30324651)
KAIHARA Satoshi  Kyoto prefectural university of medicine, graduate school of medical sciences, Associate professor, 医学部, 助教授 (70324647)
Project Period (FY) 2001 – 2003
KeywordsLiver transplantation / Living donor / Immunity seppression treatment / Memory T cell / Effecter T cell / Cytochrome P450 / P glycoprotein
Research Abstract

It aged 1998, the adult liver transplant from a living donor was introduced completely, and it came for the deployment and establishment as much as possible.
In this research period, exact analysis of the vascular construction in the computer picture analysis based on 3DCT was carried out, and the selection and operation technique of the high liver graft of safety based on this were established.
As a result, the adult liver transplant from a living donor progressed quickly in this institution, brought about expansion of an adaptation case, the increase in the number of cases, and the improvement in results, and contributed to society greatly.
However, the results do not have few examples of early death by postoperative complications by the high risk group in which various internal-organs obstacles are accepted from before an operation, either.
The greatest point for this improvement is a measure against infection accompanying each optimal immunity control treatment and immunity insufficiency to a patient.
Then, P glycoprotein analysis was performed with Cyp3a4,5 which participates in the medicine metabolism of small intestine membrane about the metabolism of immunosuppressant tecrolimus, and the difference in each patient's immunity control medicine metabolism was clarified.
Before and after operation CD45 isoform expression profiling It carried out, using sequential analysis [of a naive using T-lymph cell / memory T lymph cell, and an effecter T-lymph cell / memory T-lymph cell] in peripheral blood lymphocyte.
Consequently, we have classified recipients into five groups and established the tailor-maid immunity control treatment to determine the amount of optimal dosage and the medication method of immunosappressants according to five groups.
By this research, the adult liver transplant from a living donor can be developed more safely.

  • Research Products

    (58 results)

All Other

All Publications (58 results)

  • [Publications] Akira Katsurada: "Circulating Antibody To Hepatitis B Core Antigen Does Not Always Reflect The Latent Hepatitis B Virus Infection In The Liver Tissue"Hepatology Reserch. 25. 105-114 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Kido: "Significant Role Of Middle Hepatic Vein In Remnant Liver Regeneration Of Right-Lobe Living Donors"Transprantation. 75・9. 1598-1600 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kasahara M: "Living-Related Liver Transplantation For Alagille Syndrome"Transplantation. 75・12. 2147-2150 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ito T: "Changes In Portal Venous Pressure In The Early Phase After Living Donoe Liver Transplantation : Pathogenesis And Clinical Implications"Transplantation. 75・8. 1313-1317 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kasahara M: "Monosegmental Living Donor Liver Transplantation For Infantile Hepatic Hemangioendothelioma"J Pediatr Surg. 38・7. 1108-1111 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hideaki Okajima: "Long- Term Effect Of Liver Transplantation On Bone Mineral Density In Children With End- Stage Liver Disease : A2-Year Prospective Study"Liver Transplantation. 9・4. 360-364 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koichi Tanaka: "Progress And Future In Living Donor Liver Transplantation"The Keio Journal Of Medicine. 52・2. 73-79 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ronald W.Busuttil: "Liver Transplantation"Liver Transplantation. 9・7. 651-663 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Ito: "Surgery-Related Morbidity In Living Donors Of Rightlobe Liver Graft : Lessons From The First 200 Cases"Transplantation. 76・1. 158-163 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hedekazu Yamamoto: "Background And Clinical Impact of Tissue Congestion In Right-Lobe Livingdonor Liver Grafts : A Magnetic Resonance Imaging Study"Transplantation. 1・76. 944-950 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mikiko Ueda: "A Case Of Inflammatory Pseudotumor Of The Liver Hilum Successfully Treated With Aggressive Hepatectomy"Journal Of Pediatric Surgery. 38・11. 9-11 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hironori Haga: "Periportal Edema And Necrosis As Diagnostic Histologic Features Of Early Humoral Rejection In A B O - Incompatible Liver Transplantation"Liver Transplantation. 9・12. 1-12 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Hisatsune: "Endoscopic Management Of Billary Strictures Aafter Duct-To-Duct Biliary Reconstruction In Right-Lobe Living-Donor Liver Transplantation"Transplantation. 76・5. 810-815 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tetsuya Kiuchi: "Small-For-Saize Graft In Living Donor Liver Transplantation : How Far Should We Go?"Liver Transplantation. 9・9. 29-35 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasuhiro Ogura: "Outcomes For Pediatric Liver Retransplantation From Living Donors"Transplantation. 76・6. 943-948 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koji Umeshita: "Operative Morbidity Of Living Liver Donors In Japan"The Lancet. 362. 687-690 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takashi Ito: "Surgery-Related Morbidity In Living Donors Of Right-Robe Liver Graft : Lessons From The First 200 Cases"Transplantation. 76・1. 158-163 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mikiko Ueda: "A Case Of Inflammaatory Pseudotumor Of The Liver Hilum Successfully Tread With Aggressive Hepatectomy"Journal Of Pediatric Surgery. 38・11. 9-11 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satohiro Masuda: "Enhanced Expression of Enterocyte P-Glycoprotein Depresses Cyclosporine Bioavailability In A Recipient Of Living Donor Liver Transplantation"Liver Transplantation. 9・11. 1108-1113 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koji Umeshita: "Operative Morbidity Of Living Liverdonors In Japan"The Lancet. (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 伊藤孝司: "肝静脈再建のテクニック"外科. 65. 52-57 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松本慎一: "膵島移植の最近の進歩"医学のあゆみ. 204. 506-507 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 八木真太郎: "臓器移植と輸液・栄養管理"外科治療. 88. 290-294 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 深津祥央: "タクロリムス免疫抑制導入プロトコールの相違による治療成績・副作用発言頻度の比較検討"日本TDM学会. 20. 95-96 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上田幹子: "肝芽腫と肝移植"小児外科. 35. 591-595 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小倉靖弘: "肝移植における適応の限界"Medical science Digest. 29. 10-13 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田中紘一: "Frontiers in Gastroenterology"メディカルレビュー社. 8. 46-50 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小倉靖弘: "ABO血液型不適合生体肝移植におけるアスペルギルス感染症"日本医学館. 117-122 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小柴貴明: "生体肝移植と免疫寛容"BIO Clinica. 18. 76-81 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akira Katsurada et al.: "Circulating antibody to hepatitis B core antigen dose not always reflect the latent hepatitis B virus infection in the liver tissue"Hepatology reserch. 25. 105-114 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Kido et al.: "Significant role of middle hepatic vein in remnant liver regeneration of night-lobe living donors"Transplantation. 75,9. 1598-1600 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kasahara M et al.: "Living-related liver transplantation for alagille syndrome"Transplantation. 75,12. 2147-2150 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ito T et al.: "Changes in portal venous pressure in the early phase after living donor fiver transplantation: pathogenesis and clinical implications"Transplantation. 78,8. 1313-1317 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kasahara M et al.: "Monosegmental living donor liver transplantation for infantile hepatic hemangioendothelioma"J pediatr Surg.. 38,7. 1108-1111 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hideaki Okajima et al.: "Long-term effect of liver transplantation on bone mineral density in children with end-stage liver disease: A2-year prospective study"Liver transplantation. 9,4. 360-364 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koichi Tanaka et al.: "Progress and future in living donor liver transplantation"The Keio Journal of Medicine. 52,2. 73-79 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ronald W.Busuttil et al.: "Liver transplantation"Liver transplantation. 9,7. 651-663 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi lto et al.: "Surgery-related morbidity in living donors of rightlobe liver graft: lessons from the first 200 cases"transplantation. 76,1. 158-163 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hidekazu Yamamoto et al.: "Background and clinical impact of tissue congestion in right-lobe living donor liver grafts: A magnetic resomance imaging study"transplantation. 1,76. 944-950 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikiko Ueda et al.: "A case of inflammatory pseudotumor of the diver hilum successfully treated with aggressive hepatectomy"Journal of pediatric surgery. 38,11. 9-11 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hironori Haga et al.: "periportal edema and necrosis as diagnostic histologic features of early humoral rejection in A B O-incompatible liver transplantation"Liver transplantation. 9,12. 1-12 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi hisatsune et al.: "Endoscopic management of bilary strictures after duct-to-duct biliary reconstruction in right-lobe living transplantation"Transplantation. 76,5. 810-815 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tetsuya Kiuchi et al.: "Small-for-saize graft an living donor liver transplantation: how far should we go?"Liver transplantation. 9,9. 29-35 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuhiro Ogura et al.: "Outcomes for pediatric liver retrasnplantation from living donors"Transplantation. 76,6. 943-948 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koji Umeshita et al.: "Operative morbidity of living liver donors in japan"The lancet. 362. 687-690 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Ito et al.: "Surgery-related morbidity in living donors of right-lobe liver graft: lessons from the first 200 cases"transplantation. 76,1. 158-163 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikiko Ueda et al.: "A case of inflammatory pseudotumor of the liver hilum successfully treated with aggressive hepatectomy"Journal of pediatric surgery. 38,11. 9-11 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Satohiro Masuda et al.: "Enhanced expression of enterocyte p-glycoprotein depresses cyclosporine bioavailability in A recipient of living donor liver trasnplantation"Liver transplantation. 9,11. 1108-1113 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koji Umeshita et al.: "Operative morbidity of living liver donors in Japan"The lancet. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takashi Ito et al.: "The technique of reconstruction liver-vein"Surgery. 65. 52-57 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinichi Matumoto et al.: "The latest progress of a pancreas islet transplant"Igakunoayumi. 204. 506-507 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shintarou Yagi et al.: "An organ transplant and transfusion, nutrition management"Surgery medical treatment. 88. 290-294 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Syouou Fukatu et al.: "The comparison study of efficacy and side effect according to the induction treatment of immunosuppression"Japanese TDM society. 20. 95-96 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mikiko Ueda et al.: "Hepatoblastoma and a liver transplantation"pediatric surgery. 35. 591-595 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuhiro Ogura et al.: "The limitation of indication for liver transplantation"Medical science digest. 29. 10-13 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koichi Tanaka et al.: "Frontiers in gastroenterology"Medical review company. 8. 46-50 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuhiro Ogura et al.: "ASUPERUGIRUSU infection in an ABO incompatibility liver transplantation from a living donor"Nihonnigakukann. 18. 76-81 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takaaki Koshiba et al.: "A liver transplant from a living donor and immune tolerance"BIO clinics. 18. 76-81 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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