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2002 Fiscal Year Final Research Report Summary

PHYSIOLOGICAL ACTNITY AND OXIDATIVE STABILITY OF CONJUGATED HIGHLY UNSATURATED FATTY ACIDS

Research Project

Project/Area Number 13460089
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Fisheries chemistry
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

FUJIMOTO Kenshiro  TOHOKU UNIVERSITY, GRADUATE SCHOOL OF AGRICULTURAL SCIENCE, PROFESSOR, 大学院・農学研究科, 教授 (00005620)

Co-Investigator(Kenkyū-buntansha) MIYASHITA Kazuo  HOKKAIDO UNIVERSITY, GRADUATE. SCHOOL OF FISHERIES SCIENCE, PROFESSOR, 大学院・水産科学研究科, 教授 (10182015)
ENDO Yasushi  OHOKU UNIVERSITY, GRADUATE SCHOOL OF AGRICULTURAL SCIENCE, ASSOCIATE PROFESSOR, 大学院・農学研究科, 助教授 (60194049)
Project Period (FY) 2001 – 2002
Keywordsconjugated highly unsaturated fatty acid / conjugated trienoic acid / Ptilota pectinata / polyenoic acid isomerase / cytotoxicity on cancer cells / oxidative stability / lipid metabolism / hypolipidemic activity
Research Abstract

Conjugated trienoic fatty acids were fairy unstable in bulk phase, however cathechin was effective as an atioxidant. Dietary conjugated trienoic and highly unsaturated fatty acids did not induce lipid peroxidation in the tissues of rat or hen. Dietary conjugated fatty acids were not accumulated in the tissues but retarded the deposition of fat. Alternatively conjugate linoleic acid was observed in the tissue lipids. Conjugated trienoic acids showed a remakable cytotoxic activity on the cultured cancer cell lines. Dietary conjugated trienoic acids inhibited the azoxymethane-induced colonic aberrant crypt foci in rat. Chemopreventive activity of conjugated trienoic acid was suggested. A polyunsaturated fatty acid isomerase was isolated from a red alga Ptilota pectinata. The isomerase converted eicosapentaenoic acid and arachidonic acid to conjugated trienoic acids which were highly toxic to HepG2 cells.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Matsumoto, N., Endo, Y., Fujimoto, K., Koike, S., Matsumoto, W.: "The inhibitory effect of conjugated and polyunsaturated fatty acids on the growth of human cancer cell lines"Tohoku J.Agric.Res.. 52(1,2). 1-12 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Lee, J.S., Takai, J., Takahashi, K., Endo, Fujimoto, K., Koike, S., et al.: "Effect of dietary tung oil on the growth and lipid metabolism of laying hens"J.Nutr.Sci.Vitamiol.. 48[2]. 142-148 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki, R., Nakao, K., Ota, T., Abe, M., Miyashita, K.: "Cytotoxic effect of conjagated trienoic fatty acids on mouse tumor and human monocytic leukemis cells"Lipids. 36[5]. 477-482 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki, R., Nakao, K., Kobayashi, M., Miyashita, K.: "Oxidative stability of conjugated polyunsaturated fatty acids and their Esters in bulk phase"J.Oleo Sci.. 50[6]. 491-495 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noguchi, R., Yasui, Y., Suzuki, R., Hosokawa, M., Fukunaga, Miyashita, K.: "Dietary effects of bitter goud oil on blood and liver lipids of rats"Arch. Biochem. Biophys.. 396[2]. 207-212 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kohno, H., Suzuki, R., Noguchi, R., Hosokawa, Miyashita, K., Tanaka, T.: "Dietary conjugated linolenic acid inhibits azoxymethane-induced Colonic aberrant crypt foci in rats"Jpn.J.Cancer Res.. 93[1]. 133-142 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮下和夫: "共役型リノレン酸(CLN)によるガン予防"オレオサイエンス. 2[6]. 333-338 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Noguchi, R., Yasui, Y., Hosokawa, M., Fukunaga, K., Miyashita, K.: "Bioconversion of conjugated linolenic acid (CLN) to conjugated Linoleic acid (CLA)"Lipids. (印刷中). (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsumoto, N., Endo, Y., Fujimoto, K., Koike, S., Matsumoto, W.: "The inhibitory effect of conjugated and polyunsaturated fatty acids on the human cancer cell lines"Tohoku J. Agric. Res.. 52(1,2). 1-12 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Lee, J.S., Takai, J., Takahashi, Y., Endo, Y., Fujimoto, K., Koike, S., Matsumoto, W.: "Effect of dietary tung oil on the growth and lipid metabolism of laying hens"J. Nutr. Sci. Vitaminol.. 42(2). 142-148 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, R., Noguchi, R., Ota, T.,Abe, M., Miyashita, K., Kawada, T.: "Cytotoxic effect of conjugated trienoic fatty acids on mouse tumor and human monocytic leukemia cells"lipids. 36(5). 477-482 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, R., Nakao, K., Kobayashi, M., Miyashii, K.: "oxidative stability of conjugated polyunsaturated fatty acids and their esters in bulk phase"J. Oleo Sci.. 50(6). 491-495 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi, R., Yasui, Y., Suzuki, R., Hosokawa, M., Fukunaga, K., Miyashita, K.: "Dietary effects of bitter Gourd oil on blood and liver ipids of rats"Arch. Biochem. Biophys.. 396(2). 207-212 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kohno, H., Suzuki, R., Noguchi, R., Hosokawa, M., Miyashita, K., Tanaka, T.: "Dietary conjugated linolenic acid inhibits azoxymethane-induced clonic aberrant crypt foci in rats"Jpn. J. Cancer Re.. 93. 133-142 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyashita, K.: "Anticancer effect of conjugated linolenic acids (CLN)"Oleoscience. 2(6). 333-338 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Noguchi, R., Yasui, Y., Hosokawa, M., Fukunaga, K. Miyashita, K.: "Bioconversion of conjugated linolenic acid (CLN) to conjugated linoleic acid"Lipids. in press.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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