2003 Fiscal Year Final Research Report Summary
Clinical Research on the Development of Non-myeloablative Allogeneic Hematopoietic Stem Cell Transplantation for Refractory Gastrointestinal
| Project/Area Number |
13470259
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YAMAGISHI Hisakazu Kyoto Prefectural University of Medicine, Department of Surgery, Division of Digestive Surgery, Professor, 医学研究科, 教授 (40128723)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Yuji Kyoto Prefectural University of Medicine, Department of Surgery, Division of Digestive Surgery, Assistant Professor, 医学研究科, 助手 (60254356)
TANIWAKI Masafumi Kyoto Prefectural University of Medicine, Department of Clinical Molecular Genetics and Laboratory Medicine, Professor, 医学研究科, 教授 (80163640)
SONODA Yoshiaki Kyoto Prefectural University of Medicine, Department of Molecular-targeting of Cancer Prevention, Associate Professor, 医学研究科, 助教授 (60206688)
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| Project Period (FY) |
2001 – 2003
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| Keywords | Gastrointestinal Cancer / A1logeneic_Hematopoietic Stem Cell Transplantation / Immunotherapy / Mini-transplantation / Graft-versus-Tumor Effect |
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| Research Abstract |
Non-myeloablative allogeneic hematopoietic stem cell transplantation for refractory colon cancer was performed. The patient was a 45-year-old female with metastatic colon cancer. Metastatic sites were located in the liver, lymph nodes, and intra-peritoneal cavity (peritoneal dissemination). The donor was her HLA full-matched elder brother. After non-myeloablative and immunosuppressive chemotherapy with cyclophosphamide and fludarabine, allogeneic peripheral blood stem cell transplantation was performed (mini-transplantation). Although graft-versus-host disease (GVHD) was recognized 35 days after transplantation, tumor shrinkage didn't occur and she died of cancer 64 days after transplantation.
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[Publications] Ueda Y, Sonoda Y, Fujiki H, Harada S, Kimura T, Itoh T, Kenichiro I, Naito K, Nomura K, Taniwaki M, Yamagishi H.: "Mobilization of peripheral blood stem cells (PBSCs) after original etoposide, adriamycin, and cisplatin (EAP) therapy and a multimodal cell therapy approach with PBSCs in advanced gastric cancer."Oncol Rep. Vol.11(accepted). (2004)
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「研究成果報告書概要(欧文)」より
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[Publications] Nomura K, Yoshino T, Nakamura S, Akano Y, Tagawa H, Nishida K, Seto M, Nakamura S, Ueda R, Yamagishi H, Taniwaki M.: "Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sections by using fluorescence in situ hybridization"Cancer Genetics Cytogenetics. 140. 49-54 (2003)
Description
「研究成果報告書概要(欧文)」より
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