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2002 Fiscal Year Final Research Report Summary

Investigation of Natural Drug Resouces in Lam Dong Province, Vietnam and Shan State, Myanmar

Research Project

Project/Area Number 13576027
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Chemical pharmacy
Research InstitutionTOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY

Principal Investigator

KADOTA Shigetoshi  Toyama Med. and Pharm. Univ. Institute of Natural Medicine Professor, 和漢薬研究所, 教授 (90115163)

Co-Investigator(Kenkyū-buntansha) TEZUKA Yasuhiro  Toyama Med. and Pharm. Univ. Institute of Natural Medicine Asso. Professor, 和漢薬研究所, 助教授 (70236975)
SAIKI Ikuo  Toyama Med. and Pharm. Univ. Institute of Natural Medicine Professor, 和漢薬研究所, 教授 (80133776)
WATANABE Hiroshi  Toyama Med. and Pharm. Univ. Institute of Natural Medicine Professor, 和漢薬研究所, 教授 (10012642)
A.H. Banskota  Toyama Med. and Pharm. Univ. Institute of Natural Medicine Assist. Professor, 和漢薬研究所, 助手 (40333497)
Project Period (FY) 2001 – 2002
Keywordsagarwood / traditional medicine / Aquilaria crassna / Panax vietnamensis / liver disease / Panax zinziberensis / anti-narcotic action / Orthosiphon stamineus
Research Abstract

Investigations in Vietnam
1. We have visited traditional medicine practitioners, hospitals, research institutes for science, forestry and cultivation in Hochiminh, Da Lat, Nha Trang, Tuy Hoa and Phan Thiet Cities to study traditional medicine and the cultivation of agarwood and Taxus, cinchona, artichoke. Approximately 260 kinds of crude drugs used by the local traditional medicine practitioners have been sampled.
2. A natural alive Aquilaria crassna tree, which is known to produce agarwood, has been found in Khanh Hoa Province. We also have questioned the local people, who earn their living on agarwood, to learn about agarwood resources, proccessing, cultivation, grading and qualification. In order to preserve the natural resource of agarwood, the cultivation of A. crassna have been started in several places in Vietnam.
Investigations in Myanmar
1. We have visited traditional medicine practitioners, clinics, hospitals and drug stores in Shan State, mainly in Taunggyi and Lashio. We have interviewed traditional medicine practitioners in Taunggyi and Kyaukme to learn about proccessing and production of Shan State traditonal medicine and 75 kinds of crude drugs have been sampled. Moreover, a wild ginseng plant was found for the first time in Taunggyi.
Research in Japan
1. Extracts of Vietnamese crude drugs were prepared, creened for anti-metastasis, hepatoprotection searched for active constituents. The results have been reported in 30 articles in international scientific journal.
2. The ginseng plant collected in Myanmar was identified to be Panax zingiberensis, which faces extinction in China and is highly protected. An article on the research result is in press.
3. The result of the investigation on agarwood is to be published.
4. A review on the research of Vietnamese crude drug Alpinia blepharocalyx has been published.
5. Result on the study of the chemical constituents of a Vietnamese, Myanmar and Southeast Asian medicinal plant Orthosiphon stamineus has been published.

  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] Shigetoshi Kadota: "Novel Diarylheptanoides of Alpinia blepharocalyx"Current Topics in Medicinal Chemistry. 3. 203-225 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Arjun H.Banskota: "Chemical Constituents and Biological Activities of Vietnamese Medicinal Plants"Current Topics in Medicinal Chemistry. 3. 227-248 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suresh Awale: "Siphonols A-E : Novel Nitric Oxide Inhibitors from Orthosiphon stamineus of Indonesia"Bioorganic & Medicinal Chemistry Letters. 13. 31-35 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Jun-ya Ueda: "Antiproliferative activity of Vietnamese Medicinal Plants"Biological Pharmaceutical Bulletin. 25・6. 753-760 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suresh Awale: "Secoorthosiphols A-C ; three highly oxygenated secoisopimarane-type diterpenes from Otrhosiphon Stamineus"Tertrahedron Letters. 43. 1473-1475 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Quan Le Tran: "Hepatoprotective Effect of Majonoside R2, the Major Saponin from Vitnamese Ginseng (Panax vietnamensis)"Planta Medica. 68. 402-406 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tezuka Y.: "Eleven Novel Diarylheptanoids and Two Unusual Diarylheptanoid Derivatives from the Seeds of Alpinia blepharocalyx."J. Nat. Prod.. 64. 208-213 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ali M. S.: "Six New Diarylheptanoids from the Seeds of Alpinia blepharocalyx."J. Nat. Prod.. 64. 289-293 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Adnyana I K.: "Three New Triterpenes from the Seeds of Combretum quadrangulare and Their Hepatoprotective Activity."J. Nat. Prod.. 64. 360-363 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tran Q. L.: "Triterpene saponins from Vietnamese ginseng (Panax vietnamensis) and their hepatocytoprotective activity."J. Nat. Prod.. 64. 456-461 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ali M. S.: "Blepharocalyxins C-E, Three New Dimeric Diarylheptanoids, and Related Compounds from the Seeds of Alpinia blepharocalyx."J. Nat. Prod.. 64. 491-496 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ali M. S.: "Antiproliferative Activity of Diarylheptanoids from the Seeds of Alpinia blepharocalyx."Biol. Pharm. Bull.. 24. 525-528 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Adnyana I K.: "1-O-Galloy1-6-O-(4-hydroxy-3,5-dimethoxy) benzoyl-β-D-glucose, a New Hepatoprotective Constituent from Combretum quadrangulare."Planta Med.. 67. 370-371 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Awale S.: "Five Novel Highly Oxygenated Diterpenes of Orthosiphon stamineus from Myanmar."J. Nat. Prod.. 64. 592-596 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tran Q. L.: "New Spirostanol Steroids and Steroidal Saponins from Roots and Rhizomes of Dracaena angustifolia, and Their Antiproliferative Activity."J. Nat. Prod.. 64. 1127-1132 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Awale S.: "Secoorthosiphols A-C ; Three Highly Oxygenated Secoisopimarane-type Diterpenes From Orthosiphonstamineus."Tetrahedron Lett.. 43. 1473-1475 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Awale S.: "Four Highly Oxygenated Isopimarane-Type Diterpenes of Orthosiphon stamineus from Myanmar."Planta Med.. 68. 286-288 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ueda J.: "Antiproliferative Activity of Vietnamese Medicinal Plants."Biol. Pharm. Bull.. 25. 753-760 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tran Q. L.: "Hepatoprotective Effect of Majonoside R2, The Major Saponin from Vietnamese Ginseng (Panax vietnamensis)."Planta Med.. 68. 402-406 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Awale S.: "Norstaminane- and Isopimarane-type Diterpenes of Orthosiphon stamineus from Okinawa."Tetrahedron. 58. 5503-5512 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Awale S.: "Siphonols A-E : Novel Nitric Oxide Inhibitors from Orthosiphon Stamineus of Indenesia."Bioorg. Med. Chem. Lett.. 13. 31-35 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Awale S.: "Highly-Oxygenated Isopimarane-Type Diterpenes from Orthosiphon stamineus of Indonesia and Their Nitric Oxide Inhibitory Activity."Chem. Pharm. Bull.. 51. 268-275 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Awale S.: "Inhibition of NO production by Highly-ozygenated Diterpenes of Orthosiphon stamineus and Their Structure-Activity Relationship."Biol. Pharm. Bull.. 26. 468-473 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Awale S.: "Nitric Oxide Inhibitory Isopimarane-type Diterpenes from Orthosiphon stamineus of Indonesia."J. Nat. Prod.. 66. 255-258 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tran Q. L.: "Wild Ginseng Grows in Myanmar."Chem. Pharm. Bull., in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tran Q. L.: "A survey on agarwood in Vietnam."J. Trad. Med., in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tezuka Y.: "Studies on Biologically Active Constituenta in Southeast Asian Medicinal Plants."Natural Medicines. 56. 78-83 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kadota S.: "Novel Diarylheptanoids of Alpinia blepharocalyx."Current Topics in Medicinal Chemistry. 3. 203-225 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Banskota A. H.: "Chemical Constituents and Biological Activities of Vietnamese-Medicinal Plants."Current Topics in Medicinal Chemistry. 3. 227-248 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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