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2002 Fiscal Year Final Research Report Summary

The comparison of virus genome and immune reaction between asymptomatic carriers and chronic hepatitis patients infected with HBV.

Research Project

Project/Area Number 13670495
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

MARUYAMA Toshiyuki  The University of Tokyo, Graduate School of Medicine, Lecturer, 大学院・医学系研究科, 講師 (30219571)

Co-Investigator(Kenkyū-buntansha) MITSUI Hiroshi  The University of Tokyo, University Hospital, Research Associate, 医学部附属病院, 助手 (30239280)
MORIYA Kyouji  The University of Tokyo, Graduate School of Medicine, Lecturer, 大学院・医学系研究科, 講師 (00272550)
KOIKE Kazhiko  The University of Tokyo, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (80240703)
Project Period (FY) 2001 – 2002
KeywordsHBV-DNA / tolerance / transgenic mouse / mutation / cytokine
Research Abstract

Antigen presenting cells were induced from spleen cells of HBcAg transgenic mouse (Tg10c), or HBeAg transgenic mouse (Tg30e), and HBcAg transgenic mouse has the better ability to induce HBcAg specific antigen presenting activity, but lower ability to express HBeAg.
Antibody production against HBcAg or or HbeAg was slightly low in Tg10c, and almost lost in Tg30e.
20 asymptomatic HBV carrier patients (group A) who has no symptom and no elevation of liver function test and 25 HBV related chronic hepatitis patients (group B) were analyzed for virolo9ical profile and cYtokine production.
Although few mutations were detected in group A patients, several mutations were found in group B patients. Lots of mutations were concentrated in the core region. However, chronic hepatitis B does not appear to be caused by a specific genomic mutation or an amino acid mutation.
In the cytokine production assay, the average interleukin 2 levels were higher in group B patients than that in group A patients. Similarly, and IFNγ levels were higher in group B patients than that in group A patients.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Maruyama T.: "Anti-HBs antibodies produced after liver transplantation : from the donor or the recipient?"Hepatology. 38. 271-272 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hirayama M., Maruyama T.: "IgG1 anti-P2 as a marker of response to interferon in patients with chronic hepatitis C."Clinical Experimental Immunology.. 126. 92-100 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsui H.: "The MEK1-ERK map kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells."Int.J.Cancer.. 92. 55-62 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maekawa H., Maruyama T.: "Esophageal smooth muscle tumor in a 25-year-old Female with Congenital Malformations."Journal of Gastroenterology.. 36. 700-703 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Moriya K.: "Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis."Cancer Research. 61. 4365-4370 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Moriya K.: "Increase in the concentration of carbon 18 monounsaturated fatty acids in the liver with hepatitis C : analysis in transgenic mice and humans."Biochemical & Biophysical Research Communications.. 281. 1207-1212 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maruyama T.: "Anti-HBs antibodies produced after liver transplantation : from the donor or the recipient?"Hepalology. 38. 271-272 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hirayama M: "IgG1 anti-P2 as a marker of response to interferon inpatients with chronic hepatitis C."Clinical Experimental Immunology. 126. 92-100 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsui H.: "The MEK1-ERK map kinase pathway and the PI 3-kinase-Aktpathway independently mediate anti-apoptotic signals in HepG2 livercancer cells."Int.J.Cancer. 92. 55-62 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maekawa H: "Esophageal smooth muscle tumor in a 25-year-old Femalewith Congenital Malformations."Journal of Gastroenterology. 36. 700-703 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriya K., Koike K.: "Oxidative stress in the absence of inflammation in amouse model for hepatitis C virus-associated hepatocarcinogenesis."Cancer Research. 61. 4365-4370 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriya K., Koike K.: "Increase in the concentration of carbon 18monounsaturated fatty acids in the liver with hepatitis C : analysis intransgenic mice and humans."Biochemical & Biophysical Research Communications. 281. 1207-1212 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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