2002 Fiscal Year Final Research Report Summary
Therapeutic trial of prion infected mice by continuous infusion of anti-prion agent to brain
| Project/Area Number |
13670653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Graduate School of Biomedical Sciences, Nagasaki University |
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Principal Investigator |
SHIRABE Susumu Graduate School of Biomedical Sciences, Nagasaki University, The First Internal Medicine, associate professor, 大学院・医歯薬学総合研究科, 助教授 (40264220)
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| Co-Investigator(Kenkyū-buntansha) |
MOTOMURA Masakatsu Graduate School of Biomedical Sciences, Nagasaki University, The First Internal Medicine, lectuere, 大学院・医歯薬学総合研究科, 講師 (70244093)
NAKAMURA Tatsufumi The Department of Molecular Microbiology and Immunology Nagasaki University Graduate School of Medical Sciences, associate professor, 大学院・医歯薬学総合研究科, 助教授 (00198219)
KATAMINE Shigeru The Department of Molecular Microbiology and Immunology Nagasaki University Graduate School of Medical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (40161062)
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| Project Period (FY) |
2001 – 2002
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| Keywords | Prion / Creutz feldt・Jakob disease / Autiseuse / Monpliosimno / Treatment |
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| Research Abstract |
1) We established prion-infected cell line to evaluate in-vitro effect of anti-prion agents.
2) We screened chemical agents and already existing medicines which may have possible anti-prion effect.
3) Pentosan Polysulfate (PPS) showed maximum anti-prion effect among the agents we tested.
4) To acquirer increased ratio of brain delivery, we are try to modifying PPS by chemical reactions.
5) Morphorino failed to reduce PrPc production in vitro.
6) We established the clinical protocol of patients with Prion disease using PPS and Quinacrine.
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