Gene study related to chronic myelogenous leukemia

2002 Fiscal Year Final Research Report Summary

• Project/Area Number: 13671050
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: The University of Tokyo
• Principal Investigator: SATO Noriharu The University of Tokyo, The Institute of Medical Science, Associate Professor, 医科学研究所, 助教授 (90162461)
• Co-Investigator(Kenkyū-buntansha): TOJO Arinobu The University of Tokyo, The Institute of Medical Science, Associate Professor, 医科学研究所, 助教授 (00211681) ; SHIRAFUJI Naoki Teikyo University, Faculty of Medicine, Associate Professor, 医学部内科, 助教授 (00206301) ; ASANO Shigetaka The University of Tokyo, The Institute of Medical Science, Professor, 医科学研究所, 教授 (50134614)
• Project Period (FY): 2001 – 2002
• Keywords: SNPs / genome / Chronic myelogenous leukemia / incidence / prognosis

Research Abstract

Using DNA from patients with chronic myelogenous leukemia (CML), we determined genotypes of SNPs in genes that are possibly related to development or progression of CML. SNPs sites in the promoter region and those conferring amino acid changes in coding exon were given priority. In JSNP data base, we could find 50 SNPs in the candidates gene in the first step, including CDK2, CEBPE, CyclindD1, CYP1A1, CYP1A2, CYP2D6, GSTT2, TSTM1, IL12RB1, IL12B, IRF6, NQO1, ASB1, ASB2, CDKN1, CDKN3, GM-CSF, HDAC3, IFNGR2, JAK1, JAK3, PLCG1, TGF. In parallel with this study, we collected DNA from normal volunteers after approval of ethical board of our institute.
We could not find any genotype that has statistically significant relation with occurrence of CML. Neither could we find gene that is related to poor or good prognosis of CML.